{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:31:21Z","timestamp":1787085081670,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571536"],"award-info":[{"award-number":["32571536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271392"],"award-info":[{"award-number":["32271392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0676"],"award-info":[{"award-number":["2024NSFSC0676"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Multidrug\u2010resistant (MDR) bacterial infections and persistent oxidative stress exert a prolonged, hostile inflammatory pressure in chronic skin wounds, posing a formidable clinical challenge. Current antibiotic\u2010based modalities often fall short in inflammation resolution and cutaneous regeneration. Here, we present the design of a reactive oxygen species (ROS)\u2010balancing MXene\/MoSe\n                    <jats:sub>2<\/jats:sub>\n                    (MX\/Mo), with MoSe\n                    <jats:sub>2<\/jats:sub>\n                    synthesized on MXene surfaces via a solvothermal method. In infections, MX\/Mo under ultrasound activation promotes efficient electron\u2010hole separation to trigger a localized ROS storm. This disturbs the bacterial respiratory chain and irreversibly blocks adenosine triphosphate synthesis, causing lethal energy deprivation and MDR bacterial eradication. During healing, MX\/Mo without ultrasound exhibits significant multienzyme\u2010like activity to autonomously scavenge residual ROS, alleviating oxidative injury. In in vivo studies, MX\/Mo exhibits superior antibacterial and wound healing efficacy by rapidly suppressing severe Methicillin\u2010resistant Staphylococcus aureus infections and creating a favorable microenvironment with balanced ROS levels, thereby triggering angiogenesis and promoting collagen deposition for tissue regeneration. We anticipate that MX\/Mo addresses skin wounds with multifactorial pathologies by integrating antibacterial activity and oxidative stress regulation, which offers new possibilities for treating a broad range of bacterial infection\u2010driven disorders.\n                  <\/jats:p>","DOI":"10.1002\/smll.74325","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:11:42Z","timestamp":1782731502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ROS\u2010Balancing MXene\/MoSe\n                    <sub>2<\/sub>\n                    Hybrids Combat Drug\u2010Resistant Bacteria and Accelerate Tissue Regeneration in Cutaneous Wounds"],"prefix":"10.1002","volume":"22","author":[{"given":"Xiangnan","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"He","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Research Center for Nano\u2010Biomaterials &amp; Regenerative Medicine Department of Biomedical Engineering College of Artificial Intelligence Taiyuan University of Technology  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7150-8868","authenticated-orcid":false,"given":"Shuangquan","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-5244","authenticated-orcid":false,"given":"Yi","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010025\u201001226\u20102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.14.2.244\u2010269.2001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.044"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.01.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010019\u20100293\u20103"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100924"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02081\u20106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007530\u2010w"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)00876\u20106"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310599"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.10.022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008259"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202410031"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202524216"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500720"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.165164"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202505769"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.02.028"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.155694"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419426"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315576"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18444"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt3159"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202510741"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202501131"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202504524"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202313997"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307624"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502147"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022278\u2010x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202418731"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c01879"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.156981"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.162683"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123258"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001344\u20106"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05000"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205813"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2025.103081"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010018\u20100001\u20101"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010022\u201000591\u2010z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2025.110940"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c19373"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.455311"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbag012"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2683"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2505237122"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707503"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2010.534527"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010013\u20102825\u2010y"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2026.2654989"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u20100230\u20103"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.74325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:11:44Z","timestamp":1787083904000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.74325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":53,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/smll.74325"],"URL":"https:\/\/doi.org\/10.1002\/smll.74325","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2026-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74325"}}