{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:33:37Z","timestamp":1793504017042,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sonodynamic therapy (SDT) has enormous potential to eradicate tumors in situ and reshape antitumor immunity, but the efficacy of SDT is constrained by sonosensitizer performance and the intensity of the induced immune response. In the present study, a metal\u2013organic framework (MOF) sonosensitizer (PN20@Rx) for treating bone metastases was designed through alendronate sodium (ALN)\u2010mediated defect engineering. This strategy significantly increased sonocatalytic efficiency by narrowing the interstitial spaces and optimizing the sonic\u2010to\u2010electrical energy conversion. Furthermore, PN20@Rx exhibited multiple nanoenzyme activities and bone\u2010targeting properties, simultaneously depleting glutathione (GSH), generating hydroxyl radicals (\u2022OH), and producing oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ). In a bone metastasis model, upon ultrasound (US) stimulation, PN20@Rx effectively cleared 4T1 cells within mouse tibiae, inhibited tumor\u2010associated bone destruction, and induced multiple regulated cell death (RCD) pathways and immunogenic cell death (ICD). PN20@Rx simultaneously downregulated the expression of the CD47 immune checkpoint protein on tumor cell surfaces, thereby converting the tumor from an immune \u201ccold\u201d state to an immune \u201chot\u201d state and effectively suppressing lung metastasis. The present study provides a unique sonocatalytically enhanced strategy and novel insights for MOF\u2010based clinical tumor immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.74385","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:23:15Z","timestamp":1783354995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bone\u2010Targeted Nanosystems Induce Multiple Types of Cell Death and Suppress Osteoclasts via Sonodynamic Sensitization Therapy to Treat Bone Metastatic Tumors"],"prefix":"10.1002","volume":"22","author":[{"given":"Qingjian","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan University  Wuhan Hubei P. R. 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