{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:46:24Z","timestamp":1792082784567,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"48","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lipid nanoparticles (LNPs) have emerged as a prominent delivery vehicle for therapeutics such as mRNA vaccines and genetic medicines. However, current manufacturing technologies struggle to balance precision, scalability, and cost\u2010effectiveness. While microfluidic mixing offers excellent particle control, it often faces operational challenges, including channel fouling and a reliance on costly single\u2010use chips that create bottlenecks for reproducible and scalable production of LNPs. Conversely, bulk methods lack uniformity, and conventional extrusion remains a labor\u2010intensive batch process. Here, we report a hybrid continuous synthesis platform that integrates a reusable 3D\u2010printed milli\u2010fluidic mixer with inline membrane extrusion. By engineering a robust 3D internal architecture at the milli\u2010scale, this system achieves rapid mixing while mitigating clogging risks associated with micro\u2010channels. Our platform also offers a durable, easy\u2010to\u2010clean alternative that enhances process reproducibility while the integrated design enables single\u2010pass refinement of LNPs, streamlining the production workflow to achieve high\u2010quality, uniform LNPs at flow rates of up to 20\u00a0mL min\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Overall, our study provides a scalable, cost\u2010effective, and contamination\u2010resistant pathway for industrial LNP manufacturing, overcoming the limitations of existing disposable cartridge\u2010based systems.\n                  <\/jats:p>","DOI":"10.1002\/smll.74386","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:34:45Z","timestamp":1783071285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3D\u2010Printed Milli\u2010Fluidic Mixing\u2010Extrusion Platform for Continuous, High\u2010Throughput LNP Production"],"prefix":"10.1002","volume":"22","author":[{"given":"Leekang","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering Pohang University of Science and Technology (POSTECH)  Pohang Gyeongbuk South 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