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Electrical stimulation (ES), which mimics endogenous bioelectric cues, has emerged as a promising approach for promoting wound repair. However, many existing electroactive dressings depend on external power sources or non\u2010degradable electronic components, limiting their practicality and long\u2010term biocompatibility. To address these challenges, we developed a self\u2010powered electroactive dressing (ES\u2010GP\/ZIM) integrating a biodegradable Zn\u2500Mo galvanic cell within a trilayer electrospun scaffold loaded with icariin (ICA). In the physiological wound environment, the Zn\u2500Mo galvanic couple generates continuous localized electrical stimulation, while the intermediate layer provides sustained ICA release to regulate inflammation and angiogenesis throughout the healing process. In a full\u2010thickness skin wound model, ES\u2010GP\/ZIM markedly accelerated tissue repair, achieving \u223c85% wound closure by day 7 and near\u2010complete epithelialization by day 14. Mechanistic studies further revealed that the combined action of ES and ICA effectively modulates key cellular processes, including inflammation, fibroblast migration, collagen deposition, and neovascularization. Collectively, this biodegradable and self\u2010powered dressing provides a simple yet effective platform for active wound management and regenerative tissue repair.<\/jats:p>","DOI":"10.1002\/smll.74388","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:00:28Z","timestamp":1783083628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Self\u2010Powered Dressing Based on a Zn\u2010Mo Galvanic Cell for Accelerated Wound Repair"],"prefix":"10.1002","volume":"22","author":[{"given":"Jinna","family":"Ke","sequence":"first","affiliation":[{"name":"School of Medical Devices Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Medical Devices Shenyang Pharmaceutical University  Shenyang 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