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However, the clinical application of photodynamic therapy (PDT) is impeded by the suboptimal reactive oxygen species (ROS) generation efficiency and inadequate visualization of redox procedure. In this study, we developed a theranostic platform\n                    <jats:bold>HSF<\/jats:bold>\n                    , featuring integrated tumor\u2010specific near\u2010infrared (NIR) fluorescence imaging and photodynamic ROS generation for real time monitoring and targeted radiotherapy of solid malignancies for NPC. Mechanistically,\n                    <jats:bold>HSF<\/jats:bold>\n                    was initially activated by the elevated glutathione (GSH) levels in the tumor microenvironment, which concomitantly turned on its NIR fluorescence and photodynamic properties. The resulting NIR fluorescence allowed for tumor visualization, while the PDT\u2010triggered oxidative stress further consumed intracellular GSH, thereby ultimately inducing ferroptosis. In NPC cell\u2010derived xenograft models,\n                    <jats:bold>HSF<\/jats:bold>\n                    demonstrated exceptional biocompatibility and effective in vivo retention. This multifunctional photosensitizer enabled precise radiotherapy navigation via real time fluorescent monitoring and ferroptosis\u2010mediated therapeutic mechanisms, offering a transformative approach for real time visualization\u2010guided NPC therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.74401","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:48:46Z","timestamp":1786967326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Dual GSH\/ROS\u2010Functional NIR Fluorescent Platform for Synergistic Photodynamic Therapy and Radiosensitization in Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"22","author":[{"given":"Fan","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of General Surgery Xiangya Hospital Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Diseases Xiangya Hospital 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