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However, its widespread application has been constrained by inefficient exosome isolation and cumbersome metabolomic workflows. Herein, we introduce a \u201cmagnetic\u2010catcher\u201d composite comprising a spiky TiO\n                    <jats:sub>2<\/jats:sub>\n                    shell with 3D nano\u2010traps for efficient exosome capture via spatial complementarity and affinity interactions, and a superparamagnetic Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    core for rapid magnetic separation. Oxygen vacancies and heterointerfaces engineered on the shell enhance light absorption and charge separation, enabling the material to serve as an efficient matrix for laser desorption\/ionization mass spectrometry (LDI\u2010MS). During analysis, the particles simultaneously lyse captured exosomes and promote metabolite desorption\/ionization, achieving high sensitivity and reproducibility (CV &lt;\u00a015%).\u00a0Ultimately, an integrated magnetic\u2010catcher\/MALDI\u2010MS platform was established, which consolidates exosome isolation and metabolomic analysis into a streamlined workflow. The integrated platform was applied to plasma from pancreatic ductal adenocarcinoma (PDAC) patients, yielding high\u2010quality exosomal metabolic profiles. Machine learning analysis achieved accurate PDAC diagnosis and staging within the study cohort, with area under the curve (AUC) values of 1.000 for both tasks, and potential biomarkers (D\u2010glucose, lysine, 6\u2010methyloctanoic acid, phenyllactic acid, and 3\u2010oxodecanoic acid) were identified. Future studies involving larger, multi\u2011center cohorts are required to validate the generalizability and clinical utility of our approach.\n                  <\/jats:p>","DOI":"10.1002\/smll.74402","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:21:11Z","timestamp":1783520471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spiky Magnetic Titania Particles for Integrated Exosome Capture and Metabolic Profiling Toward Cancer Diagnosis"],"prefix":"10.1002","volume":"22","author":[{"given":"Fenghua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Department of Surgery Shibei Hospital of Jing'an District of Shanghai  Shanghai P. R. 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