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Conventional wound dressings often fail to modulate the wound microenvironment, limiting their effectiveness in chronic and infected wounds. In recent years, microgels have emerged as a promising candidate for wound healing due to their injectability, high surface area, tunable physicochemical properties, adaptability to irregular wound surface, and ability to encapsulate diverse therapeutic agents. Herein, recent advances in the design and fabrication of multifunctional microgels, highlighting their building blocks, fabrication strategies, and key characterization techniques are summarized. The application of microgels for skin wound healing is discussed, with emphasis on their roles in drug delivery, antibacterial action, antioxidant activity, and immunomodulation. Furthermore, recent progress in microgel\u2010based hybrid dressings is reviewed, where microgels are integrated with other material systems, such as hydrogels, to achieve enhanced therapeutic performance. Finally, current challenges and future perspectives related to the clinical translation of microgel\u2010based wound dressings are outlined. Overall, this review provides a comprehensive overview of microgel\u2010based strategies and underscores their growing potential in advanced wound care applications.<\/jats:p>","DOI":"10.1002\/smll.74406","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:05:12Z","timestamp":1783332312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Microgels: From Material Design to Skin Wound Healing Applications"],"prefix":"10.1002","author":[{"given":"Dimpy","family":"Bhardwaj","sequence":"first","affiliation":[{"name":"School of Chemical Sciences and Advanced Materials Research Centre Indian Institute of Technology Mandi  Mandi Himachal Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences and Advanced Materials Research Centre Indian Institute 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