{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:28:53Z","timestamp":1791325733556,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274138"],"award-info":[{"award-number":["22274138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The efficient capture and sensitive detection of exosomes from complex biological samples remain critical challenges for liquid biopsy\u2010based cancer diagnosis. Herein, we report a three\u2010dimensional flower\u2010like UiO\u201066@TiO\n                    <jats:sub>2<\/jats:sub>\n                    heterostructure that integrates on\u2010plate exosome enrichment with in situ laser desorption\/ionization mass spectrometry (LDI\u2013MS) analysis. The hierarchical flower\u2010like architecture (approximately 2\u00a0\u00b5m) provides a high surface area and abundant binding sites for exosome capture, while the Type II heterojunction between UiO\u201066 and TiO\n                    <jats:sub>2<\/jats:sub>\n                    facilitates photogenerated charge separation, significantly enhancing photothermal conversion, charge transfer, and molecular desorption upon laser irradiation. The established platform achieves a detection limit of 2.3\u00a0\u00d7\u00a010\n                    <jats:sup>5<\/jats:sup>\n                    particles per mL for exosomes with excellent reproducibility and anti\u2010interference capability. When applied to a clinical cohort of 678 serum samples from patients with prostate cancer (PCa), benign prostatic disease (BPD), and healthy controls (HC), the platform enables rapid acquisition of exosome metabolic and lipid fingerprints. Machine learning analysis of these fingerprints successfully distinguishes prostate disease (PD) from HC and PCa from BPD. In an external validation cohort, the model identified 97.1% of HC, 86.4% of BPD, and 91.3% of PCa cases. This work provides a promising strategy for exosome\u2010based liquid biopsy and highlights the potential of functional nanomaterials in precision oncology.\n                  <\/jats:p>","DOI":"10.1002\/smll.74412","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:46:42Z","timestamp":1783313202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hierarchical Flower\u2010Like UiO\u201066@TiO\n                    <sub>2<\/sub>\n                    Heterostructure for On\u2010Plate Exosome Enrichment and In Situ Metabolic Fingerprinting Toward Prostate Cancer Diagnosis"],"prefix":"10.1002","author":[{"given":"Xinrong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Urology School of Medicine Sir Run Run Shaw Hospital Zhejiang University  Hangzhou China"},{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Sir Run Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Sir Run Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichen","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Sir Run Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Sir Run Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Sir Run Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Sir Run Run Shaw Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Chen","sequence":"additional","affiliation":[{"name":"Well\u2010healthcare Technologies Co.  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