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These membraneless structures formed by liquid\u2013liquid phase separation (LLPS) self\u2010assembly have high drug\u2010loading capacity, favorable biocompatibility, and tunable responsiveness to tumor microenvironment (TME) cues. This programmability enables targeted delivery and controlled release. This review summarizes the latest progress in the design and therapeutic application of functionalized coacervates in cancer therapy. We first introduce the construction strategies, including basic driving forces, material platforms, and advanced architectures. Then, we explain the mechanisms that enhance therapeutic efficacy and reduce toxicity, including enhanced loading and stability, improved pharmacokinetics and tumor accumulation, and enhanced intracellular delivery that can overcome multidrug resistance (MDR). We also discuss spatiotemporal release triggered by TME cues, such as acidity, redox, or enzymatic activity. Next, we highlight applications in chemotherapy, nucleic acid delivery, cancer immunotherapy, multimodal combination therapy, and emerging directions. Finally, we discuss translational challenges and outline future research directions. We aim to provide a coherent framework for researchers and to facilitate the development and clinical translation of coacervate\u2010based therapeutics.<\/jats:p>","DOI":"10.1002\/smll.74466","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:45:16Z","timestamp":1785242716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase\u2010Separation\u2013Based Intelligent Drug Delivery"],"prefix":"10.1002","volume":"22","author":[{"given":"Pu\u2010Ge","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University  Nanjing People's Republic of 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