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Magnetically driven micro\/nanomotors (MNMs) offer a promising platform for localized drug delivery and in situ biofilm eradication in complex anatomical environments. However, current MNMs face critical challenges, including the serious risks of retention in vivo and insufficient propulsion within viscoelastic biofilms. Here, a laser\u2010guided self\u2010assembly strategy is developed to assemble tubular magnetic micromotors from high\u2010entropy alloy\/polyimide (HEA\/PI) bilayers for hydrogel\u2010based drug delivery and biofilm eradication inside implantable medical tubes. Programmable direct laser writing converts PI into laser\u2010induced graphene (LIG) while simultaneously inducing controlled self\u2010rolling of the HEA\/LIG bilayers into mechanically robust micro\u2010rolls. Under rotating gradient magnetic fields, these micro\u2010rolls display controllable oscillatory\u2013spiral propulsion in confined microchannels, enabling fast transport and site\u2010specific drug release. When filled with an antibiotic\u2010loaded hydrogel, the HEA\/LIG micro\u2010rolls achieve synergistic mechanical biofilm disruption and localized antibiotic release within\n                    <jats:italic>E. coli<\/jats:italic>\n                    \u2013infected pancreatic duct stents, resulting in a 97% sterilization efficiency, 44% higher than that achieved by standard chemical sterilization. This work establishes an unprecedented laser manufacturing paradigm for medical micromotors, providing a minimally invasive approach for targeted biofilm removal from hard\u2010to\u2010reach anatomical\u00a0sites.\n                  <\/jats:p>","DOI":"10.1002\/smll.74469","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:11:37Z","timestamp":1784034697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laser\u2010Guided Self\u2010Rolled Magnetic Microrobots for Targeted Biofilm Eradication in Severely Infected Medical Stents"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-4001","authenticated-orcid":false,"given":"Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Semiconductor Manufacturing Research, College of Mechatronics and Control Engineering Shenzhen University Shenzhen China"},{"name":"Division of 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