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Liposomes offer a biocompatible and adaptable foundation for this need, but no scalable approach exists to produce uniform thermosensitive liposomes that activate above 37\u00b0C. Here, we present the first scalable strategy for generating monodisperse thermoresponsive liposomes using a corona\u2010discharge\u2010 treated PDMS double\u2010emulsion device. Aqueous cargo\u2010containing cores are encapsulated within DPPC\u2010containing oleic acid shells, with Pluronic F\u2010127 added to the outer phase to stabilize the interface. Ethanol\u2010mediated solvent extraction transforms these shells into lipid bilayers, and the combined use of rotational mixing and surfactant\u2010assisted interfacial tuning reduces extraction time by more than 50% compared with prior reports while ensuring complete bilayer formation, even for thick shells. Under regulated extraction, droplets with thin lipid membranes incorporating Pluronic F\u2010127 undergo abrupt rupture and cargo release at \u223c41\u00b0C\u201345\u00b0C, providing stable encapsulation at physiological temperature and sharp thermally triggered release above body temperature. Overall, this work creates the first platform capable of producing uniform thermoresponsive liposomes that undergo abrupt, super\u2010physiological temperature\u2010triggered release, providing broad potential for drug delivery, biosensing, and synthetic biology.<\/jats:p>","DOI":"10.1002\/smll.74496","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:26:06Z","timestamp":1783769166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uniform Microscale Thermoresponsive Liposomes for Controlled Release Above Body Temperature"],"prefix":"10.1002","volume":"22","author":[{"given":"S. Morteza","family":"Mousavi","sequence":"first","affiliation":[{"name":"School of Mechanical and Manufacturing Engineering University of New South Wales  Sydney New South Wales Australia"},{"name":"School of Engineering Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Mechanical and Manufacturing Engineering University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-0890","authenticated-orcid":false,"given":"Elvis","family":"Pandzic","sequence":"additional","affiliation":[{"name":"Katharina Gaus Light Microscopy Facility Mark Wainwright Analytical Centre University of New South Wales  Sydney New South Wales 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