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However, the ECL efficiency of NCs is relatively low, which dramatically constrained their applications due to the demands of detection sensitivity and brightness. In this study, we report the interface self\u2010assembly of Au\n                    <jats:sub>10<\/jats:sub>\n                    nanoclusters for the first time, and ultimately formed a fibrous structure with a high aspect ratio, Au\n                    <jats:sub>10\u2010Fiber,<\/jats:sub>\n                    which is an innovative approach that significantly enhances the ECL activity of Au\n                    <jats:sub>10<\/jats:sub>\n                    NCs. By employing time\u2010dependent and in situ spectroscopic techniques, we visually monitored the dynamic assembly process, and elucidated the interface self\u2010assembly mechanism mediated by aurophilic interaction and \u03c0\u2013\u03c0 stacking. The increase in local electronic density, enhanced conductivity of the ordered structure, and accelerated electron transfer within the \u03c0\u2010conjugated system collectively contributed to the significant enhancement of the ECL performance, thereby revealing the key structural factors responsible for ECL enhancement. As a proof of concept, we successfully constructed an ECL immunosensor based on Au\n                    <jats:sub>10\u2010Fiber<\/jats:sub>\n                    for the detection of Alzheimer's disease biomarker A\u03b2\n                    <jats:sub>1\u201042<\/jats:sub>\n                    , achieving a detection limit below 3.33 fg\/mL.\n                  <\/jats:p>","DOI":"10.1002\/smll.74501","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:45:30Z","timestamp":1783687530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interface Self\u2010Assembly of Au\n                    <sub>10<\/sub>\n                    Nanoclusters for Enhanced Electrochemiluminescence and Alzheimer's Disease Biomarker Detection"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhiying","family":"Jin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences  Changchun Jilin P. 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