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This treatment infuses drugs directly into the peritoneal cavity to enable direct contact with and killing of tumor cells. However, its efficacy is limited by rapid drug metabolism and short effective duration. To address this limitation, researchers have explored various drug delivery systems but the limited efficacy of local scaffold treatments has hindered tumor eradication. In response, this study developed a drug delivery system based on suspended microbubbles (MBs). These suspended MBs exhibit a saline\u2010similar density, enabling suspension and uniform distribution within the peritoneal cavity. Additionally, the MBs possess ultrasound\u2010enhanced contrast performance, allowing real\u2010time monitoring of their distribution. The 5\u2010fluorouracil (5\u2010Fu)\u2010loaded suspended MBs (5\u2010Fu\u2010MBs) sustained the release of the drug and extended the duration of drug action after ultrasound\u2010guided intraperitoneal perfusion. In animal experiments, 5\u2010Fu\u2010MB perfusion demonstrated superior therapeutic efficacy and lower biotoxicity compared to conventional 5\u2010Fu solution. The results suggest that, owing to their unique suspension stability, excellent ultrasound\u2010enhanced contrast performance, and sustained drug release capability, the 5\u2010Fu\u2010MBs are not only suitable for treating PC, but also hold potential for localized precision diagnosis and therapy in other body cavities.<\/jats:p>","DOI":"10.1002\/smll.74537","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:41:53Z","timestamp":1783680113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Suspended Microbubbles With Ultrasound Visualization and Sustained Drug Release Properties for Enhancing Intraperitoneal Perfusion Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Junyi","family":"Xie","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmin","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanshuan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"},{"name":"The Cancer Center of the Fifth Affiliated Hospital Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiurong","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-8679","authenticated-orcid":false,"given":"Jianhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010021\u201000326\u20106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8679"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2020.31.e58"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28373"},{"key":"e_1_2_8_6_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology","author":"National Comprehensive Cancer Network","year":"2025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/pp\u20102017\u20100003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.0580"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.4_suppl.328"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21749"},{"key":"e_1_2_8_12_1","first-page":"515","article-title":"Gastrointestinal Cancers with Peritoneal Carcinomatosis: Surgery and Hyperthermic Intraperitoneal Chemotherapy","volume":"29","author":"Loggie B. 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