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However, their efficacy is limited by heterogeneous nanoparticle accumulation in different tumors and patients. Nuclear imaging offers non\u2010invasive, patient\u2010 and lesion\u2010specific visualization and quantification of nanoparticle uptake, providing a biomarker to predict nanotherapy efficacy. We present a positron emission tomography (PET)\u2010imageable [mPEG\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010\n                    <jats:italic>p<\/jats:italic>\n                    (HPMAm\u2010Bz)]\u2010based polymeric micelle platform for image\u2010guided and tumor\u2010targeted drug delivery, with potential for patient stratification and theranostics. Polymers with 1 or 3 deferoxamine (DFO) chelators were synthesized, and the corresponding micelles showed stable\n                    <jats:sup>89<\/jats:sup>\n                    Zr\u2010radiolabeling and efficient drug (paclitaxel) encapsulation. PET imaging revealed long in vivo circulation times and high tumor accumulation, with more DFO per polymer accelerating drug release and increasing off\u2010target accumulation. Hence, single\u2010DFO\u2010containing polymers were used to develop companion diagnostic and paclitaxel\u2010loaded theranostic micelles. Both formulations displayed comparable biodistribution profiles and high levels of tumor uptake (&gt;17% ID\/g) and were able to capture inter\u2010 and intra\u2010individual heterogeneity in tumor targeting. Importantly, cryo\u2010preservation enables long\u2010term storage while maintaining in vivo performance and tumor\u2010targeting capabilities, bolstering translational potential. Taken together, DFO\u2010functionalized \u03c0\u2010electron\u2010stabilized micelles allow direct quantification of nanoparticle accumulation in tumors while mediating effective drug delivery, showing promise for patient stratification and as a theranostic platform for image\u2010guided and personalized cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.74543","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:30:04Z","timestamp":1785411004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Theranostic \u03c0 Electron\u2010Stabilized Polymeric Micelles for PET Imaging\u2010Guided Drug Delivery to Tumors"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5198-559X","authenticated-orcid":false,"given":"Alec","family":"Wang","sequence":"first","affiliation":[{"name":"Institute For Experimental Molecular Imaging Uniklinik RWTH 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