{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:26:36Z","timestamp":1788279996671,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"49","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373481 82203920"],"award-info":[{"award-number":["82373481 82203920"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis (AD) is a skin disease characterized by impaired barrier function and immune dysregulation, in which oxidative stress imbalance plays a key pathogenic role. Current clinical therapies for AD treatment primarily target immune and inflammatory responses, but rarely address direct clearance of reactive oxygen species (ROS). To correct this imbalance, a multi\u2010enzyme\u2010mimetic nanocomposite, an Au@Mn\/Zn bimetallic metal\u2013organic framework (Au@Mn\/Zn\u2010MOF; AMZM) is constructed. Manganese sites in AMZM reversibly cycle among Mn(II\/III\/IV), thereby mimicking superoxide dismutase (SOD) and catalase (CAT) activities. Density functional theory calculations confirm that incorporated gold nanoparticles (AuNPs) optimize the electronic structure of Mn sites by stabilizing the key Mn(III) intermediate and lowering energy barriers, enabling efficient cascade scavenging of O\n                    <jats:sub>2<\/jats:sub>\n                    \u00b7\n                    <jats:sup>\u2212<\/jats:sup>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . In cellular models, AMZM suppresses ROS, stabilizes mitochondrial function, and downregulates inflammatory cytokines. In a 2,4\u2010dinitrochlorobenzene (DNCB)\u2010induced AD mouse model, topical application of polyvinyl alcohol (PVA)\u2010coated AMZM significantly alleviates skin lesions, restores barrier function, and reduces immune infiltration. Transcriptomic and mechanistic studies further indicate that AMZM exerts antioxidant and anti\u2010inflammatory effects through direct ROS scavenging and activation of the FOXO3 pathway. These results support AMZM as a nanotherapeutic strategy for AD treatment.\n                  <\/jats:p>","DOI":"10.1002\/smll.74586","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:49:13Z","timestamp":1783939753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gold Nanoparticles\u2010Embedded Mn\/Zn\u2010MOF with Enhanced Antioxidant Activities for Treating Atopic Dermatitis"],"prefix":"10.1002","volume":"22","author":[{"given":"Liping","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Institute of Dermatology Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Dermatology Ministry of Education Anhui Medical University  Hefei Anhui China"},{"name":"The Collaborative Innovation Center for Severe Skin Disorder Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Institute of Dermatology Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Dermatology Ministry of Education Anhui Medical University  Hefei Anhui China"},{"name":"The Collaborative Innovation Center for Severe Skin Disorder Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Institute of Dermatology Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Dermatology Ministry of Education Anhui Medical University  Hefei Anhui China"},{"name":"The Collaborative Innovation Center for Severe Skin Disorder Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Institute of Dermatology Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Dermatology Ministry of Education Anhui Medical University  Hefei Anhui China"},{"name":"The Collaborative Innovation Center for Severe Skin Disorder Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Institute of Dermatology Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Dermatology Ministry of Education Anhui Medical University  Hefei Anhui China"},{"name":"The Collaborative Innovation Center for Severe Skin Disorder Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Institute of Dermatology Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Dermatology Ministry of Education Anhui Medical University  Hefei Anhui China"},{"name":"The Collaborative Innovation Center for Severe Skin Disorder Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Institute of Dermatology Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Dermatology Ministry of Education Anhui Medical University  Hefei Anhui China"},{"name":"The Collaborative Innovation Center for Severe Skin Disorder Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaimeng","family":"Li","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China  Hefei China"},{"name":"Key Laboratory of Materials Physics Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and Nanotechnology Institute of Solid State Physics Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China  Hefei China"},{"name":"Key Laboratory of Materials Physics Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and Nanotechnology Institute of Solid State Physics Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-5190","authenticated-orcid":false,"given":"Fengli","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Institute of Dermatology Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Dermatology Ministry of Education Anhui Medical University  Hefei Anhui China"},{"name":"The Collaborative Innovation Center for Severe Skin Disorder Anhui Medical University  Hefei Anhui China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.01.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19580"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(25)00003\u20107"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf238"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201002174\u2010w"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.03.1680"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.70056"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108445"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2025.1790"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010022\u201001375\u2010z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c08767"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/14680009.t01\u20101\u201000006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.05.1386"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12864"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae250"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.23563"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.12.029"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.08.052"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20229"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20230066"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.72747"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202504435"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202415399"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c04419"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202510317"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.83543"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201001924\u20100"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123596"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122361"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003725\u2010z"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.02.019"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03344"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211624"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4852"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310642"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202109865"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10235"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038677\u20101"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5c14237"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07481"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c04365"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c05420"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.0c02935"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.4c10368"},{"issue":"4","key":"e_1_2_9_46_1","first-page":"242","article-title":"Stratum Corneum Hydration and Skin Surface pH in Patients With Atopic Dermatitis","volume":"19","author":"Knor T.","year":"2011","journal-title":"Acta dermatovenerologica Croatica: ADC"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15058"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202503374"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038209\u2010x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09663"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15967"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci170706"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113601"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12938"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11059"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102452"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010025\u201009057\u2010y"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.122.321542"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010022\u201000902\u20100"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.07.036"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.09.010"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2026.04.003"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2026.03.022"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaf212"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.11.045"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.74586","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:04:09Z","timestamp":1788278649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.74586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":64,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/smll.74586"],"URL":"https:\/\/doi.org\/10.1002\/smll.74586","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"2026-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74586"}}