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Understanding the situation of LD accumulation and its dynamic variations in the neural tissues of PD patients is therefore crucial for deciphering the underlying pathophysiological mechanisms of this neurodegenerative disorder. Developing a specific fluorescent probe for LDs that can also function within the brain presents a significant challenge. This study introduces a NIR (near\u2010infrared) emitting fluorescent probe, QCN\u2010TP, through step\u2010by\u2010step molecular design strategy, based on a novel framework of dye, characterized by multiple advantageous properties, including polarity sensitivity, a substantial Stokes shift (150\u2013280\u00a0nm), and aggregation\u2010induced emission (AIE). The probe, QCN\u2010TP, demonstrates remarkable sensitivity and selectivity in the recognition of LD accumulation, with enhanced deep tissue penetration capabilities. Notably, QCN\u2010TP effectively monitors both the presence of intracellular LDs and their dynamic content variations in MPP\n                    <jats:sup>+<\/jats:sup>\n                    \u2010induced PD cell models. Furthermore, the probe enables in vivo imaging of abnormal LD accumulation in the brain tissue of PD model mice. This probe offers a useful tool for real\u2010time monitoring of lipid dynamics, with potential applications in PD research and drug discovery.\n                  <\/jats:p>","DOI":"10.1002\/smll.74612","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:08:22Z","timestamp":1784113702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Constructing a NIR AIEgen Based on the Novel Molecular Framework for Imaging Lipid Droplet Accumulation in Parkinson's Disease Mouse Brain"],"prefix":"10.1002","volume":"22","author":[{"given":"Kang","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliang","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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