{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:06:33Z","timestamp":1789567593619,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQN25H030010"],"award-info":[{"award-number":["LQN25H030010"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B16029"],"award-info":[{"award-number":["B16029"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, poses a substantial global health challenge with high mortality and poor therapeutic outcomes, especially in advanced stages. Current therapeutic approaches for HCC, including surgical resection, targeted therapy, immunotherapy, and radiotherapy, are often limited by drug resistance, systemic toxicity, and the complex tumor microenvironment (TME). Herein, we establish the first wool keratin\u2010guided Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanozymes (MnWK) with self\u2010cascade catalytic capability that systematically transforms the TME into a pro\u2010oxidative microenvironment, achieving high therapeutic efficacy through synergistic hypoxia alleviation and ROS\u2010mediated apoptosis. The introduction of WK not only enhances the biocompatibility and colloidal stability of Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles, but also improves their catalytic performance to enable efficient cascade reactions under physiological conditions. Within the mildly acidic and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010rich TME, MnWK exhibits dual catalase (CAT) and oxidase (OXD)\u2010mimicking activities, driving a well\u2010defined two\u2010step catalytic cascade. Specifically, it first decomposes endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into O\n                    <jats:sub>2<\/jats:sub>\n                    to effectively alleviate tumor hypoxia, then converts the in situ generated O\n                    <jats:sub>2<\/jats:sub>\n                    into cytotoxic superoxide anions. This cascade amplifies oxidative stress and induces selective cancer cell apoptosis via the p38\/JNK MAPK signaling pathway. Overall, this work establishes a promising TME\u2010adaptive self\u2010cascade nanotherapeutic system for advancing HCC management.\n                  <\/jats:p>","DOI":"10.1002\/smll.74639","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T04:14:38Z","timestamp":1784520878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wool Keratin\u2010Engineered Manganese Nanozyme with Tumor Microenvironment\u2010Adaptive Self\u2010Cascade Capability for Hepatocellular Carcinoma Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Hongji","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang P. R. 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