{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:28:34Z","timestamp":1793582914767,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52272080"],"award-info":[{"award-number":["52272080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20200201506JC"],"award-info":[{"award-number":["20200201506JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The inherent limitations of conventional nanozymes, particularly their suboptimal catalytic activity, severely restrict their efficacy against resilient bacterial biofilms. In response, an Au\u2010Bi bimetallic nanozyme\u2010based sonosensitizer (Bi\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    @AuBi\u2010arg\/4\u2010MPBA, BABa4), which harnesses ultrasound (US) to power a multi\u2010modal antibacterial strategy, is engineered. The platform is constructed by loading the NO donor L\u2010arginine (L\u2010arg) onto a mesoporous Bi\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    @AuBi (BAB) bimetallic nanozyme and modifying its surface with a bacterial\u2010targeting ligand 4\u2010mercaptophenylboronic acid (4\u2010MPBA). Under US irradiation, Bi\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    acts as an efficient sonosensitizer, generating electron\u2010hole pairs, which not only produce singlet oxygen but also transfer to the AuBi nanozyme, markedly enhancing its POD\u2010like activity and creating a synergistic ROS storm. Concurrently, the US\u2010triggered release of nitric oxide from L\u2010arg degrades the extracellular polymeric substance (EPS) of biofilms by regulating cyclic dimeric guanosine monophosphate (c\u2010di\u2010GMP) levels. This multifaceted approach, combining sonodynamic therapy, US\u2010enhanced nanozyme catalysis, and NO\u2010mediated biofilm dispersion, demonstrates potent antibacterial activity and promotes effective wound healing, presenting a robust strategy for combating resistant bacterial infections.\n                  <\/jats:p>","DOI":"10.1002\/smll.74646","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:18:19Z","timestamp":1784629099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Solution to Nanozyme Inefficiency: Ultrasound\u2010Enhanced and Biofilm\u2010Targeted Catalytic Therapy for Eradicating Bacterial Infections"],"prefix":"10.1002","volume":"22","author":[{"given":"RuiLin","family":"Lou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, College of Integrated Circuits Jilin University  Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiFang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, College of Integrated Circuits Jilin University  Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YaQi","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, College of Integrated Circuits Jilin University  Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5831-430X","authenticated-orcid":false,"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, College of Integrated Circuits Jilin University  Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Second Affiliated Hospital of Anhui Medical University  Hefei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, College of Basic Medical Science Jilin University  Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5274-1703","authenticated-orcid":false,"given":"Biao","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, College of Integrated Circuits Jilin University  Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94907840"},{"issue":"6","key":"e_1_2_9_3_1","article-title":"Eradicating Biofilms: Decoding Persistent Mechanisms and Combating Therapeutic Strategies","volume":"15","author":"Liu Y.","year":"2025","journal-title":"Advanced Healthcare Materials"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01098-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.4c01324"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.01.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c15743"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1968"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.03.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202513863"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.260"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00457A"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.157762"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.160602"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100730"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c06833"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.139157"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR04627G"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03804"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR05514D"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416997"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406149"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202511471"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202506110"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202205997"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.215937"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102170"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.156170"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.150705"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309664"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202514995"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2025.119987"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202401931"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300777"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301349"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.08.003"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.133126"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0QI01055C"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c04920"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.01.030"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.166726"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213457"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202310706"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202201300"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.134935"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081727"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1435054"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.78.1396"},{"issue":"5","key":"e_1_2_9_49_1","first-page":"567","article-title":"First Principles Methods Using CASTEP","volume":"220","author":"Clark S. J.","year":"2005","journal-title":"Zeitschrift Fur Kristallographie"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100559"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230066"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20250127"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.74646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:13:35Z","timestamp":1793582015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.74646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":51,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/smll.74646"],"URL":"https:\/\/doi.org\/10.1002\/smll.74646","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"2025-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74646"}}