{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:06:51Z","timestamp":1789567611469,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22371044"],"award-info":[{"award-number":["22371044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22531004"],"award-info":[{"award-number":["22531004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92361301"],"award-info":[{"award-number":["92361301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Well\u2010defined gold clusters that are water\u2010soluble and photoluminescent are promising candidates for diverse applications in biological systems. We present here an unconventional approach that imparts water solubility to atomically precise gold clusters, which is achieved through\n                    <jats:italic>de novo<\/jats:italic>\n                    surface modification with dimethoxymethyl (formaldehyde dimethyl acetal) groups. By attaching dimethoxymethyl on pyridyl groups in [(C)(Au\u2010dppy)\n                    <jats:sub>6<\/jats:sub>\n                    Ag\n                    <jats:sub>2<\/jats:sub>\n                    ](BF\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>4<\/jats:sub>\n                    (\n                    <jats:bold>1<\/jats:bold>\n                    , dppy = 2\u2010pyridyldiphenylphosphine), the solubility of resulted cluster [(C)(Au\u2010L\n                    <jats:sup>a<\/jats:sup>\n                    )\n                    <jats:sub>6<\/jats:sub>\n                    Ag\n                    <jats:sub>2<\/jats:sub>\n                    ](BF\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>4<\/jats:sub>\n                    (\n                    <jats:bold>2a<\/jats:bold>\n                    , L\n                    <jats:sup>a<\/jats:sup>\n                    = 2\u2010(4\u2010dimethoxymethylpyridyl)diphenylphosphine) in water is significantly enhanced, while its molecular structure and intense photoluminescence (PL) are well reserved. Notably,\n                    <jats:bold>2a<\/jats:bold>\n                    exhibits a high quantum yield (QY) of 32.7% in H\n                    <jats:sub>2<\/jats:sub>\n                    O under ambient conditions. The universality of this approach is demonstrated by the addition of dimethoxymethyl groups on C@Au\n                    <jats:sub>6<\/jats:sub>\n                    Ag\n                    <jats:sub>2<\/jats:sub>\n                    \u2010, C@Au\n                    <jats:sub>6<\/jats:sub>\n                    Ag\n                    <jats:sub>4<\/jats:sub>\n                    \u2010, and C@Au\n                    <jats:sub>6<\/jats:sub>\n                    \u2010type clusters, giving water\u2010soluble products whose identities have been confirmed by single\u2010crystal x\u2010ray diffraction (SCXRD) and ESI\u2010MS in H\n                    <jats:sub>2<\/jats:sub>\n                    O. Furthermore, cell imaging results indicate that\n                    <jats:bold>2a<\/jats:bold>\n                    can enter the nucleus of living cells in aqueous medium, which is accumulated in the nucleolus. This approach is anticipated to serve as a highly practical means for modifying the water solubility of atomically precise metal clusters toward bioimaging and related applications.\n                  <\/jats:p>","DOI":"10.1002\/smll.74695","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T04:05:18Z","timestamp":1784520318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Unconventional Approach Imparting Structurally Well\u2010Defined Photoluminescent Gold Clusters With Water Solubility"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2947-108X","authenticated-orcid":false,"given":"Zhen","family":"Lei","sequence":"first","affiliation":[{"name":"Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated Materials, College of Chemistry Fuzhou University  Fuzhou P. R. China"},{"name":"College of Chemistry and Chemical Engineering Xiamen University  Xiamen P. R. China"},{"name":"Department of Chemistry Tsinghua University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated Materials, College of Chemistry Fuzhou University  Fuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Kun","family":"Dai","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated Materials, College of Chemistry Fuzhou University  Fuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4888-1604","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Xiamen University  Xiamen P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-6409","authenticated-orcid":false,"given":"Quan\u2010Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Xiamen University  Xiamen P. R. China"},{"name":"Department of Chemistry Tsinghua University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00703"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00896"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00800K"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11031"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adx6639"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7123234"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.1999.4123"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2202"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201101059"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2011.06.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cs00114g"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214184"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk6628"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physchem.58.032806.104546"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC47512C"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT01395D"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01055C"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/prechem.3c00036"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja042218h"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200901425"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jz3007436"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201916675"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja035473v"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.93.077402"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906766"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01366"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC02931J"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00256"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja411643u"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b04210"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700203"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.9b02920"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912984"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja046114i"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4cc02261k"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b05689"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906425"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023568\u20100"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC04594G"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.5560\/znb.2013\u20103075"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc01702g"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01068"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1148624"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2023.11.014"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202103290"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.11.001"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja906695h"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja4075419"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC02873J"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201406761"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702522"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202201549"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.20210060"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10450"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201031891\u20103"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC01976D"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049295\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data for2a: C121H120B4N6O12F16P6Ag2Au6 a= 18.0965(17) b= 47.541(2) c= 16.2790(8) \u00c5 \u03b1=\u03b2=\u03b3= 90.0\u00b0 V= 14005.3(16) \u00c53 orthorhombic space groupPbcn Z= 4 T= 173.0(1) K 29580 reflections measured 12297 unique (Rint= 0.0752) finalR1 = 0.0803 wR2 = 0.1874 for 7134 observed reflections [I> 2\u03c3(I)]. Crystal data for2b: C115H114B4N12O12F16P6Ag2Au6 a= 15.2558(7) b= 15.4866(8) c= 16.0718(11) \u00c5 \u03b1= 64.279(6) \u03b2= 78.087(5) \u03b3= 68.307(4) \u00b0 V= 3173.8(4) \u00c53 triclinic space groupP\u20101 Z= 1 T= 100.00(10) K 41181 reflections measured 11409 unique (Rint= 0.0613) finalR1 = 0.0634 wR2 = 0.1753 for 8034 observed reflections [I> 2\u03c3(I)]. Crystal data for4: C133H150B6N12O24F24P6Ag4Au6 a= 17.223(3) b= 17.518(3) c= 29.160(7) \u00c5 \u03b1= 88.360(6) \u03b2= 88.602(7) \u03b3= 80.132(6) \u00b0 V= 8662(3) \u00c53 triclinic space groupP\u20101 Z= 2 T= 150 K 365894 reflections measured 30886 unique (Rint= 0.0965) finalR1 = 0.0860 wR2 = 0.2169 for 23553 observed reflections [I> 2\u03c3(I)]. Deposition numbers 952300 (for2a) 2466110 (for2b) and 2466111 (for4) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202600011"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.5b03985"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202515551"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.02.032"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.74695","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:25:44Z","timestamp":1789565144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.74695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":65,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/smll.74695"],"URL":"https:\/\/doi.org\/10.1002\/smll.74695","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]},"assertion":[{"value":"2026-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74695"}}