{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:06:32Z","timestamp":1789567592489,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007100","name":"Sandler Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic diabetic wounds are characterized by prolonged inflammation, elevated reactive oxygen species (ROS), impaired angiogenesis, and delayed healing, often leading to tissue necrosis and amputation. Conventional wound dressings rarely address oxidative stress, dysregulated inflammation, bacterial infection, and local hyperglycemia simultaneously. Here, we developed a multifunctional nanoplatform consisting of tannic acid (TA)\u2010complexed chitosan\u2010polyethylenimine\u2010phenylboronic acid (CPB\u2010TA) nanoparticles embedded within a thermoresponsive poly(N\u2010isopropylacrylamide\u2010co\u2010acrylic acid) [P(NIPAm\u2010co\u2010AAc)] hydrogel. CPB\u2010TA nanoparticles exhibit dual cfDNA\u2010scavenging and antioxidant activity, sequestering cfDNA through combined cationic binding and polyphenol interactions, and reducing ROS via complementary antioxidant mechanisms, thereby dampening inflammatory signaling and protecting reparative cells. The phenylboronic acid groups reversibly capture glucose through dynamic boronate ester bonds, helping to alleviate local hyperglycemia. The hydrogel matrix is designed to be responsive to body temperature, promoting localized delivery of CPB\u2010TA at the wound site. In vitro, CPB\u2010TA nanoparticles promoted macrophage polarization from M1 to M2, protected endothelial cells from oxidative damage, and exhibited antibacterial activity against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . In vivo, topical application of CPB\u2010TA@hydrogel accelerated wound closure, enhanced re\u2010epithelialization, and increased collagen deposition in non\u2010infected and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010infected diabetic mouse models. This multifunctional, mechanism\u2010targeted strategy provides a rational, disease\u2010relevant approach for treating chronic diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/smll.74712","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:07:27Z","timestamp":1785244047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Polyphenol\u2010Polymer Nanocomposite Hydrogel Targeting Inflammation, Oxidative Stress, and Infection in Diabetic Wounds"],"prefix":"10.1002","volume":"22","author":[{"given":"Yuefei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"},{"name":"Department of Pathology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"},{"name":"The Plastic Surgery Department of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxu","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"},{"name":"Department of Otolaryngology The Sixth Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Sixth Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3639-8083","authenticated-orcid":false,"given":"Teertha","family":"Ayanji","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California  San Francisco California USA"},{"name":"The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam W.","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University  New York New York USA"},{"name":"Department of Systems Biology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112176"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1628252"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11700"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba4311"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.12.014"},{"issue":"7","key":"e_1_2_10_8_1","article-title":"Evolving Trends in the Management of Diabetic Foot Ulcers: A Narrative Review","volume":"16","author":"Ogbeide O. 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