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In this work, we systematically investigate the size\u2010dependent antiviral activity of ACE2\u2010conjugated nanodecoys against a safe SARS\u2010CoV\u20102 mimic. Our results demonstrate that the inhibition of mimic cellular uptake is highly size\u2010dependent. The 10\u00a0nm nanodecoys exhibited the most potent neutralization, followed by the comparable 5 and 20\u00a0nm, while the 50 and 100\u00a0nm nanodecoys demonstrated similar, lower efficacies. This work identifies nanodecoy size as a critical design principle, providing a rational framework for engineering high\u2010performance antiviral nanotherapeutics to combat SARS\u2010CoV\u20102 and other viral pathogens.<\/jats:p>","DOI":"10.1002\/smll.74751","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:37:51Z","timestamp":1784803071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Size\u2010Dependent Neutralization Efficacy of Nanodecoys Against SARS\u2010CoV\u20102 Mimics in Mammalian Cell Infection Models"],"prefix":"10.1002","volume":"22","author":[{"given":"Nan","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences Xiamen University  Xiamen 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