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In response to functional requirements, extensive studies have been conducted to improve the antioxidant properties of eumelanin\u2010like materials, but the dilemma brought by the oxidative polymerization strategy has never been broken. Herein, the natural eumelanin precursor, levodopa, was integrated with formylphenylboronic acid through dynamic covalent chemistry to give antioxidant nanoparticles. Benefiting from this synthetic scheme, the resulting dynamic nanoscavengers avoided the loss of antioxidant moieties during the fabrication process and could achieve interesting ROS\u2010responsive degradation behaviors. These nanoscavengers exhibited over ten times the antioxidant capacity of conventional eumelanin\u2010like materials and demonstrated improved efficacy in hepatic ischemia\u2010reperfusion injury therapy, with treatment groups showing more optimal levels of oxidative stress markers and inflammation\u2010related factors. This study provides new insights into the design and development of a new generation of melanin\u2010inspired antioxidant materials.<\/jats:p>","DOI":"10.1002\/smll.74752","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:27:37Z","timestamp":1785140857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Nanoscavengers With Boosted Antioxidative Properties for Hepatic Ischemia\u2010Reperfusion Injury Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Xianheng","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian China"},{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Li","sequence":"additional","affiliation":[{"name":"College of 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