{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:04:13Z","timestamp":1790006653958,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560614"],"award-info":[{"award-number":["82560614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Radiotherapy, particularly radio\u2010catalytic therapy, demonstrates immense potential in eliciting anti\u2010tumor effects. However, its efficacy is substantially constrained by the low energy conversion efficiency of x\u2010rays, limited reactive oxygen species (ROS) generation pathways, and the hypoxia\u2010induced radio\u2010resistance within the tumor microenvironment. Herein, we developed a spherical Cu\/Lu\/Tb co\u2010doped CaF\n                    <jats:sub>2<\/jats:sub>\n                    nanozyme coated with hyaluronic acid (CLTC@HA), which simultaneously exhibits highly efficient energy conversion and multifunctional catalytic activities, enabling a synergistically enhanced radio\u2010catalytic therapy through doping engineering. The collaborative interplay of Cu\/Lu\/Tb ions enables precise control over the crystal lattice, leading to tailored morphology and modulated bandgap in CLTC@HA, consequently enhancing its radio\u2010sensitization efficacy. CLTC@HA reveals multicatalytic activity through intrinsic peroxidase (POD)\u2010like activity of CaF\n                    <jats:sub>2<\/jats:sub>\n                    crystal, co\u2010doping enhanced radio\u2010catalytic property, and Cu\u2010mediated redox cycle. Crucially, the introduced Cu\n                    <jats:sup>+<\/jats:sup>\n                    \/Cu\n                    <jats:sup>2+<\/jats:sup>\n                    valence cycle efficiently depletes glutathione and promotes hydroxyl radical production via POD\u2010like activity. Consequently, CLTC@HA provokes a severe redox imbalance, effectively reversing the hypoxic radio\u2010resistance and ultimately achieving superior anti\u2010tumor efficacy. Notably, the optimal treatment group reaches a tumor growth inhibition rate of 99.1%. Furthermore, benefiting from abundant high\u2010Z elements, CLTC@HA exhibits prominent\n                    <jats:italic>\n                      T\n                      <jats:sub>1<\/jats:sub>\n                    <\/jats:italic>\n                    \u2010weighted imaging capability. This work presents a promising one\u2010component nanoplatform for advanced radio\u2010catalytic therapy and preclinical imaging.\n                  <\/jats:p>","DOI":"10.1002\/smll.74763","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:34:43Z","timestamp":1785137683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Doping Engineering Inspired Calcium Fluoride Nanozymes With Multifunctional Oxidative Storm for Enhanced Radio\u2010Catalytic Therapy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7219-8349","authenticated-orcid":false,"given":"Jun","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Material Sciences and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Material Sciences and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wubin","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Material Sciences and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Material Sciences and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Material Sciences and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Material Sciences and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-5119","authenticated-orcid":false,"given":"He","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Material Sciences and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Experimental Research University Engineering Research Center of Oncolytic &amp; Nanosystem Development (Guangxi) Guangxi Medical University Cancer Hospital  Nanning People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9555-1803","authenticated-orcid":false,"given":"Piaoping","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Material Sciences and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101510"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b01818"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051\u2010014\u20102807\u20102"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.05.022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010019\u20100530\u20108"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.05.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101099"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.9b03280"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202503576"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050416\u20108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2025.2465312"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S359156"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853\u2010024\u201009793\u20100"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/exp2.70144"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00746E"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b03682"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202003653"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03590"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121023"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704136"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn506130t"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.07.092"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12040371"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201601325"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10584587.2014.911633"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR03065B"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2011.10.005"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16121614"},{"key":"e_1_2_8_32_1","article-title":"Triple\u2010Kill Nano\u2010Disruptor Integrating Ion Interference, Metabolic Inhibition, and Immune Activation for Augmented Apoptosis and Pyroptosis\u2010Mediated Immunotherapy","volume":"38","author":"Zhang S.","year":"2025","journal-title":"Advanced Materials"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417198"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200358s"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010019\u20100373\u20106"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.74763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:25:02Z","timestamp":1790004302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.74763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":34,"journal-issue":{"issue":"53","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/smll.74763"],"URL":"https:\/\/doi.org\/10.1002\/smll.74763","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74763"}}