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An ideal surfactant should integrate delivery function with intrinsic bioactivity, yet such dual\u2010purpose molecules are rare. Here, we transform vitamin C into a fluorinated surfactant (F\u2010VC) via mild, short\u2010chain fluorination, preserving its redox\u2010active core while introducing amphiphilicity. The resulting molecule retains potent antioxidant capacity and exhibits pronounced surface activity, enabling the one\u2010step fabrication of nanoemulsions with built\u2010in antioxidant function\u2014a paradigm shift from conventional inert carriers. In vitro, F\u2010VC nanoemulsions outperform equimolar vitamin C by 43% in radical scavenging, achieve 89.4% wound closure in scratch assays, and kill up to 99% of Staphylococcus aureus. In a diabetic rat model, they drive 99% wound closure by day 14. Mechanistically, they suppress inflammatory cytokines (IL\u20106, TNF\u2010\u03b1) while promoting angiogenesis markers (CD31, \u03b1\u2010SMA). By merging therapeutic and delivery functions in a single molecular entity, F\u2010VC simplifies formulation, efficiently encapsulates diverse oil\u2010soluble bioactives, and establishes a new class of bioactive surfactants. This work establishes a new class of bioactive surfactants\u2014transforming vitamin C into a functional nanomaterial at the nexus of materials science and biomedicine.<\/jats:p>","DOI":"10.1002\/smll.74809","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:21:36Z","timestamp":1785140496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transforming Vitamin C Into a Fluorinated Antioxidant Surfactant for Bioactive Nanoemulsions in Diabetic Wound Healing"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4210-6597","authenticated-orcid":false,"given":"Lei","family":"Kang","sequence":"first","affiliation":[{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang China"},{"name":"Zhejiang Key Laboratory of Soft Matter Biomedical Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou 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