{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:21:12Z","timestamp":1791894072730,"version":"4.3.4"},"reference-count":80,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lack of intrinsic healing potential in cartilage, accompanied by accelerated inflammation and oxidative stress, creates a major clinical challenge for effective treatment of osteoarthritis (OA). This highlights the need for the development of minimally invasive, multifunctional biomaterials capable of tuning the degenerative joint microenvironment. Herein, we designed a compartmentalized dual\u2010drug injectable hydrogel (DD gel) matrix offering rapid inflammation control and sustained chondroprotective function to address the multifaceted challenges of OA. The hydrogel incorporating celecoxib acts as a primary compartment to attain an immediate anti\u2010inflammatory response, whereas the chondroitin sulfate encapsulated GelMA microspheres act as a secondary compartment to facilitate chondroprotection and joint homeostasis. Moreover, the simple and crosslinker\u2010free technique offers rapid gelation at physiological temperature, ensuring good injectability, mechanical strength, and shear\u2010thinning properties. Further, the DD gel significantly improves chondrocyte proliferation, migration, and extracellular matrix (ECM) synthesis while effectively alleviating LPS\u2010induced inflammation, oxidative stress, and ECM degradation. Additionally, in vivo implantation of DD gel stimulates the regeneration of cartilage tissue in a rabbit full\u2010thickness cartilage defect model up to 8 weeks and achieves healing close to the native cartilage tissue. This single injectable system presents a promising approach for the combinatorial therapy for OA.<\/jats:p>","DOI":"10.1002\/smll.74820","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:16:07Z","timestamp":1785492967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Compartmentalized Dual\u2010Drug Injectable Hydrogel for Anti\u2010Inflammatory Activity and Osteoarthritic Cartilage Repair"],"prefix":"10.1002","volume":"22","author":[{"given":"Chevella","family":"Maheshwari","sequence":"first","affiliation":[{"name":"Centre For Nanotechnology Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chalamala Balagangadhar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Radiology West Bengal University of Animal &amp; Fishery Sciences  Kolkata West 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