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Notably, the excessive osteoclastic differentiation of OPCs potently disrupts the osteogenesis\u2010angiogenesis coupling to promote osteoclast\u2010mediated osteolysis while dismantling the pro\u2010osteogenic type H vascular niches, resulting in elevated risk of implant destabilization. To address this issue, here we report a biomineralization\u2010tuned extracellular matrix (ECM)\u2010mimetic biomineralized coating (TCC@Har\u2010CaG) to enable redox rewiring of OPCs for promoting new bone formation. Specifically, we employed collagen\u2010I as the substrate material to fabricate the stimuli\u2010responsive biomineralized coating for the cooperative delivery of antioxidative gallic acid (GA) and osteoclast precursor cell inhibitor Harmine. The TCC@Har\u2010CaG coating could sustainably release GA after implantation to effectively relieve reactive oxygen species (ROS) stress at the osteoporotic bone defects, which could synergize with Harmine to efficiently induce OPC quiescence and restore osteogenesis\u2010angiogenesis coupling, thus cooperatively promoting new bone generation. This study presents a potential tactic for addressing osteoporotic bone fractures in clinical settings.<\/jats:p>","DOI":"10.1002\/smll.74822","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:03:02Z","timestamp":1785243782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ECM\u2010Mimetic Biomineralized Ti Implant Coating Mediates Quiescence of Osteoclast Precursor Cells to Restore Osteogenesis\u2010Angiogenesis Coupling for Accelerating Osteoporotic Fracture Repair"],"prefix":"10.1002","volume":"22","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory 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