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Herein, we report a high\u2010performance electrochemical immunosensor enabled by a hierarchical hybrid architecture comprising Ru nanodots anchored on titanium oxynitride nanoflakes dispersed on graphene oxide (Ru\/TiON\u2010GO), linked via APTES to biorecognition building blocks. The engineered heterostructure exhibits advanced electrocatalytic activity, arising from synergistic electronic coupling between Ru nanodots and the highly conductive TiON\u2010GO support, effectively promoting interfacial electron transport between the electrocatalytic surface and the [Fe(CN)\n                    <jats:sub>6<\/jats:sub>\n                    ]\n                    <jats:sup>3\u2212\/4\u2212<\/jats:sup>\n                    redox probe. Leveraging this electrocatalytic platform, a prostate\u2010specific antigen (PSA) impedimetric immunosensor was constructed, achieving a limit of detection of 0.06\u00a0ng mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    (2.3 pM) and a wide linear response covering clinically relevant concentration range. The immunosensor demonstrates excellent selectivity in human serum, operating in interference\u2010free mode even in the presence of common coexisting biomolecules, highlighting suitability for medical diagnostics. Density functional theory calculations further elucidate the origin of the enhanced electrocatalytic performance, with charge density difference plots and density of states analysis revealing Ru\u2010driven electron redistribution and increased density of states near the Fermi level. This work establishes the Ru\/TiON\u2010GO nanocomposite as a robust electrocatalytic platform for advanced immunosensing applications, paving the way toward next\u2010generation electrochemical diagnostic devices.\n                  <\/jats:p>","DOI":"10.1002\/smll.74840","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:54:24Z","timestamp":1785927264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrocatalytically Amplified Immunosensing Enabled by Titanium Oxynitride\u2010Supported Ru Nanodots on Graphene Oxide Hybrid Architecture"],"prefix":"10.1002","volume":"22","author":[{"given":"Mitja","family":"Koderman","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry National Institute of Chemistry  Ljubljana Slovenia"},{"name":"Faculty of Chemistry and Chemical Technology, University of Ljubljana  Ljubljana 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