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To address the limitations of mercury thermometers and existing sensors in visualized real\u2010time screening, three monomers S\u20101, S\u20102, and S\u20103 featuring flexible aliphatic chains and ester terminals, anhydride terminals, and aromatic rings with amide hydrogen bonds and \u03c0\u2013\u03c0 stacking are designed and polymerized into Poly(S\u20101), Poly(S\u20102), and Poly(S\u20103), respectively. Among these polydiacetylenes (PDAs) with symmetric functionalization, Poly(S\u20101) exhibits a multi\u2010step, naked\u2010eye\u2010visible thermochromic transition within 35\u00b0C\u201343\u00b0C, attributed to its flexible aliphatic chains and ester linkages that enable side\u2010chain motion and main\u2010chain conformational changes at low temperatures. In contrast, the rigid structural motifs present in Poly(S\u20102) and Poly(S\u20103) introduce stronger intermolecular forces and higher energy barriers, necessitating elevated temperatures to induce comparable thermochromic transitions. Notably, Poly(S\u20101) is successfully fabricated into a functional patch; its irreversible thermochromic nature within the physiological range meets the requirements of disposable medical devices, helping to prevent cross\u2010infection and facilitating temperature recording. This study enables precise tuning of the thermochromic temperature of PDA materials, expands their applications in biomedical monitoring and smart responsive materials, and offers design insights and theoretical foundations for developing next\u2010generation visual body temperature sensors.<\/jats:p>","DOI":"10.1002\/smll.74850","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:51:51Z","timestamp":1785228711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disulfide\u2010Linked Symmetrical Polydiacetylene as Visualized Temperature Sensor for Heatstroke Monitor"],"prefix":"10.1002","volume":"22","author":[{"given":"Xuan","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University of Science and Technology  Nanjing People's Republic of 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