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In this system, IL\u20102 serves as an essential cytokine for supporting the survival, expansion, and functional maintenance of \u03b3\u03b4T cells, while zoledronate further promotes the proliferation and activation of \u03b3\u03b4T cells, thereby enhancing their antitumor immune response. In a subcutaneous human osteosarcoma xenograft model, local delivery of CAR\u2010\u03b3\u03b4T cells combined with zoledronate and IL\u20102 via this hydrogel system significantly suppressed tumor progression and extended survival. This study thus presents an immunomodulatory strategy to potentiate \u03b3\u03b4T cell\u2010based therapy against solid tumors.<\/jats:p>","DOI":"10.1002\/smll.74877","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:56:36Z","timestamp":1786719396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Gelatin\u2010Oxidized Dextran Hydrogel for Co\u2010Delivery of \u03b3\u03b4T Cells and Immunostimulatory Agents Potentiates Local Cancer Immunotherapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Qiaofeng","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou Jiangsu People's Republic of 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