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However, their therapeutic efficacy is limited by diffusion barriers within dense tumor tissues and low catalytic efficiency in the mild tumor microenvironment. Herein, Ag\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010decorated mesoporous silica\u2010coated CeVO\n                    <jats:sub>4<\/jats:sub>\n                    \u2010based near\u2010infrared\u2010powered nanorockets were designed and synthesized for enhanced\u2010penetrating synergistic photothermal\u2010catalytic tumor therapy. In this construct, the CeVO\n                    <jats:sub>4<\/jats:sub>\n                    core acts as a redox\u2010active chemical engine within the permeable silica shell, facilitating glutathione depletion and reactive oxygen species (ROS) generation from endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . The anchored Ag\n                    <jats:sub>2<\/jats:sub>\n                    S nanoparticles endow the nanorockets with the capability of NIR\u2010driven self\u2010propulsion behavior via active thermophoresis. Under NIR irradiation, the localized heat drives the nanorockets to overcome diffusion barriers and reach internal tumor reservoirs. Simultaneously, this thermal effect accelerates catalytic reaction kinetics, thereby establishing a self\u2010sustaining therapeutic loop. This approach addresses the limitations of poor tissue penetration and low functional coupling, providing a motility\u2010enhanced, self\u2010amplifying anti\u2010tumor strategy.\n                  <\/jats:p>","DOI":"10.1002\/smll.74890","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:40:27Z","timestamp":1785318027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010Powered CeVO\n                    <sub>4<\/sub>\n                    \/Ag\n                    <sub>2<\/sub>\n                    S Redox Nanorocket for Tumor Penetration and Self\u2010Sustaining Catalytic Therapy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-7442","authenticated-orcid":false,"given":"Xiangwei","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Woody Oil Resources Utilization Center for Innovative Research in Synthetic Chemistry and Resource Utilization College of Chemistry Chemical Engineering and Resource Utilization Northeast Forestry University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Woody Oil Resources Utilization Center for Innovative Research in Synthetic Chemistry and Resource Utilization College of Chemistry Chemical Engineering and Resource Utilization Northeast Forestry University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2425-932X","authenticated-orcid":false,"given":"Paul E. 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