{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:06:53Z","timestamp":1790345213714,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"54","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071383"],"award-info":[{"award-number":["32071383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Commercial inorganic hemostatic agents such as QuikClot Combat Gauze (QCG) and WoundStat demonstrate strong hemostatic efficacy, yet their clinical utility is limited by issues such as exothermic reaction and foreign body response. To address these limitations, a cellulose nanofiber\u2010based hemostat was developed to replicate the coagulation mechanism of zeolite. This was achieved by first covalently grafting carboxymethylated cellulose nanofibers (CMCNFs) onto medical gauze to form a stable, negatively charged nanofibrous network. Subsequently, calcium ion (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) was incorporated into this network via ion exchange, yielding the final Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010chelated, citrate\u2010crosslinked CMCNF gauze (CC\/Ca\u2010gauze). The negatively charged surface and chelated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    promoted local adsorption of coagulation\u2010associated proteins and supported thrombin generation and fibrin clot formation. In vitro assays confirmed good hemocompatibility\/cytocompatibility and potent procoagulant activity of CC\/Ca\u2010gauze. In vivo evaluations further demonstrated its superior hemostatic performance, achieving faster hemorrhage control and significantly reduced blood loss compared to QCG. These results support CC\/Ca\u2010gauze as a promising cellulose\u2010based hemostatic platform for rapid hemorrhage control.\n                  <\/jats:p>","DOI":"10.1002\/smll.74902","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:08:24Z","timestamp":1785319704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zeolite\u2010Mimetic Hemostatic Gauze Based on Calcium\u2010Chelated Cellulose Nanofibers for Efficient and Safe Hemostasis"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhiping","family":"Jin","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology School of Life Sciences East China Normal University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-223X","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology School of Life Sciences East China Normal University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruicai","family":"Xia","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology School of Life Sciences East China Normal University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Stomatology Changzheng Hospital Naval Medical University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Pharmaceutical Group Co., Ltd.  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