{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:48:12Z","timestamp":1792698492159,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"55","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM142752"],"award-info":[{"award-number":["R35GM142752"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cytokine storm drives the organ damage and mortality observed in sepsis, severe infection, and systemic inflammatory diseases. Despite decades of clinical effort, eliminating pathological cytokines from circulation remains an unmet medical need due to the risk of broad immunosuppression, significant toxicity, and off\u2010target effects. Herein, guided by lipidomic insights from cytokine\u2010sequestering lipid nanoparticles isolated from\n                    <jats:italic>Lepidium meyenii<\/jats:italic>\n                    Walp., we reverse\u2010engineered triglyceride\u2010ceramide lipid nanoparticles (TCNP) as a simplified synthetic nanoplatform that harnesses multimodal protein corona formation to broadly sequester pathological cytokines involved in systemic inflammatory disease. Rather than targeting a single cytokine axis, TCNPs were tuned to adsorb and neutralize multiple pro\u2010inflammatory mediators through multimodal protein corona formation. TCNP were further engineered to encapsulate dexamethasone (Dex), conferring an additional layer of intracellular immunomodulation to complement extracellular cytokine scavenging. This dual function nanoplatform exhibited selective reduction of pro\u2010inflammatory cytokines, including IL\u20106 and TNF\u2010\u03b1 while increasing regulatory IL\u201010 and suppressing NF\u2010\u03ba\u0392 activation. In vivo, Dex\u2010loaded TCNP attenuated systemic inflammation, preserved organ integrity, and significantly improved survival in a lethal lipopolysaccharide\u2010induced endotoxemia rescue model. Collectively, these findings establish TCNP as a bioinspired nanotherapeutic platform that integrates extracellular cytokine sequestration with intracellular drug\u2010mediated immunomodulation to overcome key limitations of conventional anti\u2010inflammatory therapies.\n                  <\/jats:p>","DOI":"10.1002\/smll.74914","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:48:29Z","timestamp":1785322109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reverse\u2010Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-4424","authenticated-orcid":false,"given":"Junsik J.","family":"Sung","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Maryland School of Pharmacy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-9943","authenticated-orcid":false,"given":"Gargi Yogesh","family":"Digholkar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Maryland School of Pharmacy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7857-0973","authenticated-orcid":false,"given":"Ryan M.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Maryland School of Pharmacy  Baltimore Maryland USA"},{"name":"Department of Microbiology and Immunology University of Maryland School of Medicine  Baltimore Maryland USA"},{"name":"Marlene and Stewart Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine  Baltimore Maryland 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