{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:59:02Z","timestamp":1790884742840,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"55","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["25ZR1402150"],"award-info":[{"award-number":["25ZR1402150"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemotherapy is still widely used for combating solid tumors, yet its bottleneck is often associated with off\u2010target toxicity and weak immune activation. Herein, we report a TME\u2010activatable nanoplatform based on MnO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    to load graphene quantum dot (GQD\/MnO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    ) for tumor\u2010specific chemo\u2010immunotherapy. By comparing MnCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010, MnF\n                    <jats:sub>3<\/jats:sub>\n                    \u2010, and KMnO\n                    <jats:sub>4<\/jats:sub>\n                    \u2010derived MnO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    , we find that Mn(III)\u2010derived MnO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    exhibits the highest O\n                    <jats:sub>V<\/jats:sub>\n                    content (27.2%) and GQD loading efficiency (61.35%). Specifically, coordination between pyrrolic N in GQDs and Mn\n                    <jats:sup>3+<\/jats:sup>\n                    suppresses Mn(III) disproportionation, promoting O\n                    <jats:sub>V<\/jats:sub>\n                    formation and improving GQD encapsulation. MnO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    carrier passivates the DNA damage effect of GQDs against normal cells while undergoing GSH\u2010triggered degradation in tumors to release GQDs and Mn ions. Upon tumor\u2010specific disassembly, released GQDs bind the DNA major groove and induce DNA damage for improved chemotherapy. Concurrently, Mn\n                    <jats:sup>4+<\/jats:sup>\n                    \u2010mediated GSH depletion promotes ferroptosis and reverses the immunosuppressive TME, whereas released Mn\n                    <jats:sup>2+<\/jats:sup>\n                    activates cGAS\u2010STING pathway to promote DC maturation and activate T cells. This cascade amplification of antitumor immune response mediated by GQD\/MnO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    achieves effective inhibition effect on the growth of primary and distant tumors without recurrence. Overall, this work highlights activity passivation engineering for the utilization of TME\u2010responsive nanoplatforms for tumor\u2010specific chemotherapy amplified immunotherapy through triggering ferroptosis and activating cGAS\u2010STING pathway.\n                  <\/jats:p>","DOI":"10.1002\/smll.74930","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:27:13Z","timestamp":1785414433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mn(III)\u2010Derived MnO\n                    <sub>2\u2010x<\/sub>\n                    Passivated Graphene Quantum Dots for Tumor\u2010Specific Chemo\u2010Immunotherapy Through Triggering Ferroptosis and Activating cGAS\u2010STING Pathway"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-5641","authenticated-orcid":false,"given":"Jinyan","family":"Hu","sequence":"first","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Surgery, School of Traditional Chinese Medicine the First Affiliated Hospital of the Naval Medical University (Changhai Hospital) Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2035-5706","authenticated-orcid":false,"given":"Zhenlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Health Toxicology, College of Naval Medicine Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4819-2577","authenticated-orcid":false,"given":"Bijiang","family":"Geng","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongren Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Huadong Hospital Fudan University  Shanghai 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