{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:59:19Z","timestamp":1790884759760,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"55","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102020\u2010NR049568"],"award-info":[{"award-number":["RS\u20102020\u2010NR049568"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u201000165505"],"award-info":[{"award-number":["RS\u20102022\u201000165505"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Preclinical screening is critical for reducing drug attrition; however, current electromechanical platforms are often restricted by the trade\u2010off between miniaturization and force sensitivity. Miniaturizing sensor dimensions to enable high\u2010throughput assays inherently increases structural stiffness, rendering conventional devices incapable of resolving the weak contractile forces of cardiomyocytes. Here, we report a miniaturized cantilever\u2013MEA platform that overcomes this limitation to enable simultaneous, highly sensitive assessment of cardiomyocyte contractility and electrophysiology. By integrating an ultrathin nanosilicon piezoresistive strain sensor with an intrinsically compliant polymer microcantilever array, the device effectively decouples geometric scaling from sensitivity degradation. It detects cardiac forces down to 6.9\u00a0nN with a stress resolution of 0.042\u00a0nN\u00a0\u00b5m\n                    <jats:sup>\u22122<\/jats:sup>\n                    , supporting high\u2010density integration without compromising signal fidelity. Using neonatal rat ventricular myocytes and human induced pluripotent stem cell\u2013derived cardiomyocytes, we evaluated functional parameters including contractile force, beating rate, and extracellular field potentials. Pharmacological testing with blebbistatin, verapamil, and astemizole produced distinct electromechanical response patterns consistent with their known mechanisms. In addition, continuous monitoring under doxorubicin exposure over 48\u00a0h captured time\u2010dependent deterioration of both mechanical and electrical activity. This miniaturized dual\u2010mode platform addresses the limitations of macroscopic bulk\u2010averaging sensors, providing a scalable, label\u2010free approach for mechanistic studies and next\u2010generation cardiotoxicity screening.\n                  <\/jats:p>","DOI":"10.1002\/smll.74949","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:40:34Z","timestamp":1785397234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Cantilever\u2013MEA Platform for High\u2010Sensitivity and Scalable Recording of Cardiomyocyte Electromechanics"],"prefix":"10.1002","volume":"22","author":[{"given":"Haolan","family":"Sun","sequence":"first","affiliation":[{"name":"MEMS and Nanotechnology Laboratory School of Mechanical Engineering Chonnam National University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Li","sequence":"additional","affiliation":[{"name":"MEMS and Nanotechnology Laboratory School of Mechanical Engineering Chonnam National University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunkumar","family":"Shanmugasundaram","sequence":"additional","affiliation":[{"name":"MEMS and Nanotechnology Laboratory School of Mechanical Engineering Chonnam National University  Gwangju Republic of Korea"},{"name":"Advanced Medical Device Research Center for Cardiovascular Disease Chonnam National University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7028-8001","authenticated-orcid":false,"given":"Eung\u2010Sam","family":"Kim","sequence":"additional","affiliation":[{"name":"Lab. of Cell Mechanotransduction &amp; BioMimetics Department of Biological Sciences Chonnam National University Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3191-4222","authenticated-orcid":false,"given":"Bong\u2010Kee","family":"Lee","sequence":"additional","affiliation":[{"name":"Multiscale Molding &amp; Manufacturing (M3) Lab School of Mechanical Engineering Chonnam National University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Weon","family":"Lee","sequence":"additional","affiliation":[{"name":"MEMS and Nanotechnology Laboratory School of Mechanical Engineering Chonnam National University  Gwangju Republic of Korea"},{"name":"Advanced Medical Device Research Center for Cardiovascular Disease Chonnam National University  Gwangju Republic of Korea"},{"name":"Center for Next\u2010Generation Sensor Research and Development Chonnam National University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4609"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3845"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1743677"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2016.06.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.079"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c04868"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.131495"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/s16081258"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2015.08.024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2023.134992"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6AN01577H"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c05365"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2023.134014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112210"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117294"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c04260"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c06655"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113380"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.1c00486"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4782"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c04676"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202311274"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4915500"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2019.126995"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.118173"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2016.08.163"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201504755"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.04.011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1LC20557A"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.033"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1088\/0960\u20101317\/13\/6\/312"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0924\u20104247(91)85017\u2010I"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.146858"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010018\u20100189\u20101"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mee.2022.111854"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1088\/0960\u20101317\/20\/4\/045024"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C002478C"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41528\u2010018\u20100037\u2010x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200700333"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115756"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0507800"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237\u2010014\u20100624\u20102"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.6.467"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.05.004"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00631.2023"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00080"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.211458"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300558"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.34"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21476"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081412"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.12.047"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2112"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.11.031"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.9.989"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108167.1999.tb00264.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008\u20106363(02)00846\u20105"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00554.2015"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010020\u20100348\u20101"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010021\u201003614\u2010x"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.74949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:44:52Z","timestamp":1790883892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.74949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":60,"journal-issue":{"issue":"55","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/smll.74949"],"URL":"https:\/\/doi.org\/10.1002\/smll.74949","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"2026-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74949"}}