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NIR\u2010driven photothermal (PTT) and photodynamic therapies (PDT) have emerged as promising non\u2010antibiotic approaches due to their noninvasive nature and precise spatiotemporal controllability. However, single\u2010modality NIR treatments remain constrained by potential thermal damage to healthy tissues and reduced efficacy within the infection microenvironment. To address these limitations, researchers have developed NIR\u2010mediated multimodal strategies that integrate complementary mechanisms for synergistic antimicrobial effects. Despite increasing studies, a systematic overview of NIR\u2010based synergistic antibacterial strategies remains lacking. This review provides the first comprehensive focus on the combined application of NIR\u2010mediated PTT\/PDT with gas therapy (GT), chemodynamic therapy (CDT), immunotherapy, antibiotic adjuvants, and sonodynamic therapy (SDT). 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