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Cubic or spherical iron oxide nanoparticles, with nanocubes selected for their superior MHT performance, were coated with cetyltrimethylammonium bromide to enable aqueous ZIF\u20108 shell growth. Shell thickness strongly influenced heating efficiency under alternating magnetic fields (AMFs), with thinner shells and cubic cores yielding enhanced MHT performance. Doxorubicin (Doxo) was used as a model chemotherapeutic drug and loaded either by surface adsorption or via in\u2010situ encapsulation during ZIF\u20108 growth, the latter achieving an exceptional loading efficiency of 98%. To ensure stability in physiological environments, an amphiphilic polymer coating was applied, improving dispersion while regulating shell degradation and drug release. Doxo\u2010loaded composites exhibited efficient cellular uptake and lysosomal localization in glioblastoma and breast cancer cells. Confocal microscopy revealed that magnetic field exposure induced lysosomal permeabilization and redistribution of Doxo, indicating a potential lysosomal escape mechanism. Notably, enhanced cytotoxicity occurred only when AMFs were applied to Doxo\u2010loaded composites, despite no measurable bulk temperature increase, suggesting localized MHT\u2010induced intracellular damage. Overall, shell\u2010tunable magnetic\u2010MOF nanohybrids emerge as promising platforms for controlled, heat\u2010free intracellular drug activation for targeted cancer therapy.<\/jats:p>","DOI":"10.1002\/smll.74972","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:40:02Z","timestamp":1786380002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seeded\u2010Growth of ZIF\u20108 onto Magnetic Nanoparticles: Smart Nanocarriers with Ultrahigh Drug Loading for AMF\u2010Triggered Release"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5022-7460","authenticated-orcid":false,"given":"Ana Maria","family":"Panaite","sequence":"first","affiliation":[{"name":"Istituto Italiano di Tecnologia (IIT)  Genoa Italy"},{"name":"Universita degli Studi di Genova (UniGe)  Genoa 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