{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:43:16Z","timestamp":1791877396611,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"56","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174017"],"award-info":[{"award-number":["22174017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    RNA demethylase plays a crucial role in the dynamic regulation of m\n                    <jats:sup>6<\/jats:sup>\n                    A modification and has been identified as promising biomarker and therapeutic target. However, real\u2010time monitoring of its activity in living cells remains challenging due to poor probe stability, and lack of tumor selectivity. Herein, we develop a cancer\u2010targeting, endogenous\u2010activated DNA nanosponge (DNS) platform for cancer\u2010selective FTO imaging. The DNS is constructed via rolling circle amplification and loaded with FTO\u2010responsive DNAzyme probes (FDz) and photosensitizer zinc phthalocyanine (ZnPc) to form FDz\u2010ZnPc@DNS. The FDz are initially silenced by m\n                    <jats:sup>6<\/jats:sup>\n                    A modification and conjugated to DNS via glutathione (GSH)\u2010cleavable disulfide linkage. Upon folate receptor\u2010mediated internalization of FDz\u2010ZnPc@DNS into cancer cells, intracellular GSH triggers the release of FDz. Subsequent FTO\u2010mediated demethylation reactivates the DNAzyme, leading to amplified fluorescence recovery for FTO imaging. Concurrently, under 660\u00a0nm laser illumination, ZnPc generates cytotoxic singlet oxygen to destroy cancer cells\/tissues via photodynamic therapy. Both in vitro and in vivo studies validate the feasibility of this nanoplatform for cancer\u2010selective imaging and effective treatment. This work presents a robust and versatile nanoplatform that merges targeted delivery and endogenous activation for precise cancer imaging and therapy, with the potential for adaptation to diverse sensing and therapeutic payloads through modular reprogramming.\n                  <\/jats:p>","DOI":"10.1002\/smll.74992","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:06:36Z","timestamp":1785488796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Modular Endogenous\u2010Responsive DNA Nanosponge for Cancer\u2010Selective RNA Demethylase Imaging and Concurrent Photodynamic Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Yun","family":"Han","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-8013","authenticated-orcid":false,"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 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