{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T10:50:00Z","timestamp":1791629400311,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"56","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Peptide\u2010based nanocarriers offer unique opportunities for programmable self\u2010assembly (SA), yet rational design strategies that couple structural control with biological function remain limited. In particular, fluoropeptides have been largely inaccessible as modular building blocks until the recent availability of enantiomerically pure fluorinated amino acids (FAAs) in gram\u2010scale quantities, preventing their systematic use in functional nanomaterials. Here, we introduce fluorination as a quantitative molecular design parameter to program peptide SA, morphology, and biological performance. A homologous series of amphiphilic fluoropeptide\u2013RGD conjugates was constructed in which the degree of side\u2010chain fluorination is precisely controlled. We show that fluorination does not monotonically enhance assembly, but instead defines a narrow design window in which compact, non\u2010amyloid fibrillar architectures emerge. Mechanistic insight from molecular dynamics (MD) simulations reveals how fluorine\u2010induced modulation of hydrophobic interactions and hydration disrupts classical \u03b2\u2010sheet packing. The optimized trifluorinated conjugate exhibits high drug\u2010loading capacity, pH\u2010triggered release, receptor\u2010specific cellular uptake, and low cytotoxicity, while remaining enzymatically degradable. Together, these results establish fluorinated peptide segments as a previously inaccessible and programmable handle for the rational design of peptide\u2010based nanocarriers.<\/jats:p>","DOI":"10.1002\/smll.74993","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:59:21Z","timestamp":1785733161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluorination as a Molecular Design Parameter for Programming Peptide Nanocarriers"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8183-2150","authenticated-orcid":false,"given":"Maurizio","family":"Iannuzzi","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Fiedler","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Haoues","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvrat","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-9700","authenticated-orcid":false,"given":"Hossein","family":"Batebi","sequence":"additional","affiliation":[{"name":"Department of Physics Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7769-4774","authenticated-orcid":false,"given":"Anil","family":"Kumar 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