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However, conventional MN\u2010based theranostic systems mainly rely on passive diffusion and often involve complicated operational procedures, limiting delivery efficiency and real\u2010time responsiveness. To overcome these limitations, MNs have been integrated with enhancement strategies such as magnetic fields, acoustics, and electronics to achieve active and programmable biomedical functions. Among these approaches, bioelectronics offer unique advantages in flexibility, conductivity, signal processing, and closed\u2010loop control, thereby expanding the capabilities of MN systems in drug delivery and biosensing. Despite rapid progress, current studies mainly focus on material development and device fabrication, while the underlying design logic of bioelectronic MN systems remains insufficiently discussed. Herein, this review summarizes the recent advances in MN\u2010assisted bioelectronic systems and proposes a bioelectronic design framework based on \u201cfront\u2010end,\u201d \u201cmid\u2010end,\u201d and \u201cback\u2010end\u201d functionalities. This framework provides a systematic understanding of how biointerfaces, signal transduction, and electronic modules cooperatively govern system performance. By highlighting the integration mechanisms and architectural strategies of bioelectronic MNs, this review offers insights into the rational design of next\u2010generation wearable and closed\u2010loop biomedical platforms.<\/jats:p>","DOI":"10.1002\/smll.75022","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:56:08Z","timestamp":1785840968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioelectronic Considerations in Biomedical Microneedles"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5262-2197","authenticated-orcid":false,"given":"Le","family":"Luo","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Shenzhen University  Shenzhen China"},{"name":"College of Physics and Optoelectronic Engineering Shenzhen University  Shenzhen 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