{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T10:50:02Z","timestamp":1791629402267,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"56","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM155449"],"award-info":[{"award-number":["R35GM155449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Granular hydrogels are biomaterials composed of densely packed microparticles forming microporous structures. Their architecture can be controlled by tuning microparticle size, shape, and packing density. However, the mechanical properties of granular hydrogels mainly depend on interparticle interactions, whereby increasing the separation distance between microparticles to improve void volume weakens overall mechanical properties and induces unjamming, severely limiting their design and applicability. This study develops Thermo\u2010Responsive Granular Hydrogels (TRGHs) with adjustable interparticle spacing and preserved mechanical integrity through incorporating a temporary thermo\u2010responsive and cell\u2010invadable interstitial matrix. It is shown that the interstitial space can be increased by more than 150% and the storage modulus can be increased by 4 orders of magnitude from 5 to 8900\u00a0Pa and maintained at this level by first processing at 5\u00b0C and then increasing the temperature to 37\u00b0C. Crucially, TRGHs show improved extrudability and structural integrity after 3D printing, support enhanced in vitro cell migration from embedded spheroids, and permit uninhibited in vivo cell and vessel invasion after subcutaneous injection. By addressing the trade\u2010off between interparticle space and mechanical properties, these advanced biomaterials broaden the design possibilities for granular hydrogels in biofabrication, in vitro disease modeling, and tissue repair.<\/jats:p>","DOI":"10.1002\/smll.75043","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:42:49Z","timestamp":1786030969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reconciling Granular Hydrogel Microstructure and Mechanics via a Temporary Thermo\u2010Responsive and Cell\u2010Invadable Matrix"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-3984","authenticated-orcid":false,"given":"Jun","family":"Kim","sequence":"first","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana 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