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Here, we developed a multifunctional, programmed surface coating (Ti@Mo\u2010m\/Q) constructed from a molybdenum (Mo)\u2010doped biomimetic porous layer designed to sequentially coordinate bone regeneration. In the initial stage, with mild near\u2010infrared (NIR) irradiation the outermost quercetin (Q) layer promotes M2 macrophage polarization through the FoxO\/NF\u2010\u03baB signaling pathway, establishing a regenerative immune microenvironment while controlling antibiotic release. Subsequently, intermediate layer acts as an NIR\u2010responsive \u201con\u2010demand\u201d antibiotic reservoir, achieving &gt;99% bactericidal efficacy against oral pathogens, including\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ,\n                    <jats:italic>E. coli<\/jats:italic>\n                    , and\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    . Finally, the innermost Mo\u2010doped biomimetic ceramic film enhances osteogenesis, supported by the NIR\u2010responsive antibacterial activity of the underlying Ti@Mo layer. Generally, these findings indicate that the Ti@Mo\u2010m\/Q coating significantly improves interfacial osseointegration by strategically aligning with the physiological progression of bone regeneration while providing tunable immunomodulatory and antibacterial functions, thereby offering a promising framework for next\u2010generation implant surface engineering.\n                  <\/jats:p>","DOI":"10.1002\/smll.75054","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:51:16Z","timestamp":1786438276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Dental Implant With Programmed Surface Platform for Enhanced Interfacial Osseointegration via Sequentially Regulating Bone Regeneration With Switchable Immunomodulatory and Antibacterial 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People's Republic of China"},{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University) Ministry of Education  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Materials and Energy Southwest University  Chongqing People's Republic of China"},{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University) Ministry of Education  Chongqing People's Republic of 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