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Cuproptosis, a copper\u2010dependent cell death pathway, offers a novel anticancer strategy that is currently constrained by the poor solubility of copper complexes and lack of tumor selectivity. To overcome this limitation, a biomimetic nanoplatform was developed by co\u2010encapsulating copper diethyldithiocarbamate (CuET) and a photothermal agent into epigallocatechin gallate\u2010assisted nanoparticles, which was followed by coating with a hybrid cell membrane from cancer cells and programmed cell death protein 1 (PD\u20101)\u2010overexpressing CTLL\u20102 cells. This strategy allowed synergistic induction of cuproptosis, mild photothermal therapy (PTT), and PD\u20101\/programmed death\u2010ligand 1 (PD\u2010L1) checkpoint blockade. The nanoplatform exhibited excellent stability, photothermal efficiency, and tumor\u2010targeting capability, resulting in responsive degradation within the tumor microenvironment. In vitro and in vivo studies using breast tumor models showed that these nanoparticles displayed potent cytotoxicity, causing immunogenic cell death and dendritic cell maturation. Transcriptomic analysis revealed significant enrichment of key biological pathways. Specifically, both immune\u2010activation and cuproptosis\u2010related pathways were markedly upregulated. The combination of mild PTT and PD\u20101\/PD\u2010L1 blockade enhanced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell infiltration and established long\u2010term immune memory. This multifunctional nanoplatform provides an integrated strategy for potentiating cuproptosis\u2010augmented immunotherapy in breast cancer.\n                  <\/jats:p>","DOI":"10.1002\/smll.75095","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:15:15Z","timestamp":1786029315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Boosting Cancer Immunotherapy by Integrating Cuproptosis and Mild Photothermal Therapy in a Biomimetic Nanoplatform"],"prefix":"10.1002","author":[{"given":"Yunhui","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery West China Hospital Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshan","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Science Xihua University  Chengdu People's Republic 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