{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:44:55Z","timestamp":1791888295711,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"57","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304403"],"award-info":[{"award-number":["82304403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20220910"],"award-info":[{"award-number":["Y20220910"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Psoriasis is a chronic autoimmune skin disease affecting 2%\u20133% of the global population. Existing therapies, including topical agents, systemic immunosuppressants, and phototherapy, often suffer from limited efficacy, skin irritation, or serious side effects, highlighting the urgent need for more effective and safer alternatives. Notably, restoring the dynamic balance between regulatory T (Treg) cells and T helper 17 (Th17) cells has emerged as a promising strategy for halting psoriatic progression. Here, we developed a redox\u2010responsive nanoparticle\u2010based topical hydrogel, PB\u2010MJ@N\/G, that co\u2010delivers morin (a natural PPAR\u03b3 activator that promotes Treg proliferation) and JPH203 (a LAT1 inhibitor that suppresses Th17 cell expansion) to modulate the Treg\/Th17 balance in psoriatic skin. These drugs were co\u2010loaded into PLA nanoparticles and further coated with bilirubin\u2010conjugated poly\u2010L\u2010lysine (PB), enabling surface charge reversal and promoting local skin association and nanoparticle\u2010associated delivery into psoriatic skin. In response to the oxidative microenvironment, oxidation\u2010associated changes in the bilirubin\u2010containing PB coating increased its hydrophilicity and facilitated accelerated local drug release. In both in vitro and in vivo models, PB\u2010MJ@N significantly restored the Treg\/Th17 ratio, alleviated psoriatic inflammation, and attenuated relapse\u2010associated lesion development in a recurrence model. This topical, stimuli\u2010responsive nanoparticle presents a powerful immunotherapeutic strategy for psoriasis, supporting sustained treatment\u2010associated benefit.<\/jats:p>","DOI":"10.1002\/smll.75126","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:26:42Z","timestamp":1786512402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Redox\u2010Responsive Nanoplatform Modulating the Treg\/Th17 Balance Through LAT1\u2010 and PPAR\u03b3\u2010Related Pathways for Psoriasis Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Xinyu","family":"Jiang","sequence":"first","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Department of Pharmaceutics School of Pharmacy Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Huang","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Han","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Tao","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1810-4146","authenticated-orcid":false,"given":"Belquis","family":"Dakhane","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhao","family":"Lin","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingchao","family":"Shen","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxian","family":"Hou","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-6578","authenticated-orcid":false,"given":"Shisheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-9075","authenticated-orcid":false,"given":"Qing","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5312-7820","authenticated-orcid":false,"given":"Helin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Chen","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-4279","authenticated-orcid":false,"given":"Longfa","family":"Kou","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of Pharmacy The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)61128\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010024\u201002846\u2010z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2021\u20100257"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001655\u20106"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051690"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19380"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.678355"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010018\u20108702\u20103"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030730"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg6007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040391"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107906"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040568"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.04.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.08.059"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102510"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.528267"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010022\u201000849\u20109"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133956"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.628629"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12091882"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020359"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.037"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.106598"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45292"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300319"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203397"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2023.100782"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101875"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201032668\u20109"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201004431\u20104"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2019.01.009"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101887"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010025\u201000630\u20105"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2022.100116"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302313"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.804415"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac019"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204\u2010021\u201000154\u20107"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102430"},{"issue":"11","key":"e_1_2_9_44_1","first-page":"1363","article-title":"Biologics that Inhibit the Th17 Pathway and Related Cytokines to Treat Inflammatory Disorders","volume":"17","author":"Balato A.","year":"2017","journal-title":"Expert Opinion on Biological Therapy"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052719"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.05.008"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010023\u201001381\u20100"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048794"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.572858"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102471"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2025.100369"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010024\u201001376\u2010y"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.azn.2025.02.006"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404274"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202113269"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2026.101127"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.143173"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:48:31Z","timestamp":1791884911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":56,"journal-issue":{"issue":"57","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/smll.75126"],"URL":"https:\/\/doi.org\/10.1002\/smll.75126","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75126"}}