{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:45:01Z","timestamp":1791888301598,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"57","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1207600"],"award-info":[{"award-number":["2022YFA1207600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62375289"],"award-info":[{"award-number":["62375289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62175262"],"award-info":[{"award-number":["62175262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Photodynamic therapy (PDT) offers the advantages of non\u2010invasiveness, non\u2010drug resistance, and high selectivity. However, its efficacy against melanoma is substantially limited by tumor hypoxia, elevated glutathione levels, and the strong antioxidant and light\u2010absorbing properties of melanin. Herein, we developed a cascade\u2010amplified biomimetic nanoplatform (Cyan\u2010Cu) by assembling cyanobacteria (Cyan) and DSPE\u2010PEG\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    \u2010decorated copper (II) phthalocyanine (CuPc) for enhanced melanoma therapy. Under 635\u00a0nm laser irradiation, the Cyan\u2010Cu not only simultaneously generates both reactive oxygen species and heat for immunophototherapy, but also functions as a cocktail drug delivery system. In contrast to conventional microalgae used merely as photosynthetic oxygen generator or delivery vector, the Cyan effectively suppresses tyrosinase activity, thereby limiting the synthesis of antioxidant melanin and significantly potentiating both PDT and cuproptosis. Notably, the photothermal effect cascades to trigger Cyan disintegration into small cytotoxic fragments, enabling deeper tumor penetration for amplified anti\u2010tumor efficacy. In vivo studies demonstrated that the Cyan\u2010Cu platform reduced intratumoral melanin content while suppressing bilateral tumor growth via dual\u2010mode immune activation. This work underscores the pivotal role of Cyan in antimelanoma therapy and illustrates the therapeutic potential of the Cyan\u2010Cu platform as a multimodal synergistic strategy.\n                  <\/jats:p>","DOI":"10.1002\/smll.75166","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:05:22Z","timestamp":1786381522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cascade\u2010Amplifying Immunophototherapy Nanoplatform Integrating Cocktail Drug Delivery"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7783-9953","authenticated-orcid":false,"given":"E","family":"Pang","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Central South University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyu","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Central South University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojing","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Central South University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-3285","authenticated-orcid":false,"given":"Jianing","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Gland Surgery Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xize","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering Central South University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-3665","authenticated-orcid":false,"given":"Xiuli","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU\u2010CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Mechanical and Electrical Engineering Central South University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-6386","authenticated-orcid":false,"given":"Xiangzhi","family":"Song","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Central South University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8233-8798","authenticated-orcid":false,"given":"Pengfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU\u2010CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-2115","authenticated-orcid":false,"given":"Minhuan","family":"Lan","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Central South University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010024\u201000850\u2010w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319073"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202208721"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043890\u2010z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c05617"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202400933"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903545"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.201900012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c13241"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045072\u2010x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba5996"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912824"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.153656"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202411070"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121688"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18954"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00041"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202004733"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05638"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113744"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaq1293"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010024\u201001721\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201509397"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2016.11.011"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188968"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.912621"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117551"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08600"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2011.07.012"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/215188a0"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001784\u20101"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c06338"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202311549"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2025.102750"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c13501"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2022.08.030"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202419376"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008510\u2010w"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202416265"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419598"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206932"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.04.019"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:49:10Z","timestamp":1791884950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":44,"journal-issue":{"issue":"57","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/smll.75166"],"URL":"https:\/\/doi.org\/10.1002\/smll.75166","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"2026-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75166"}}