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However, current electrical stimulation strategies often lack stable directional output, wound\u2010conformal integration, and simultaneous control over infection\u2010associated inflammation. Here, we developed a near\u2010infrared (NIR)\u2010responsive eutectic gel (CBD, 1.25 S\/m at 25\u00b0C) that generates centripetal thermoelectric stimulation and enables controlled carbon monoxide (CO) release under a single NIR input. Upon 808\u00a0nm NIR irradiation, CBD rapidly generated local temperature (\u223c15\u00b0C within 60 s), establishing a deeply penetrating centripetal electric field (response time &lt; 1 s, current up to 3.0\u00a0\u00b5A) while enabling NIR\u2010triggered CO release. In vitro, CBD exhibited potent antibacterial and antibiofilm activity, favorable cytocompatibility, and pro\u2010migratory effects on repair\u2010related cells. In a\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    \u2010infected rat wound model, CBD + NIR treatment markedly reduced bacterial burden, attenuated excessive inflammatory responses, and promoted calcium\u2010associated regenerative signaling, as supported by transcriptomic enrichment and increased p\u2010CaMKII\/p\u2010CREB expression. These effects were accompanied by enhanced keratinocyte and endothelial cell responses, angiogenesis, collagen deposition, and re\u2010epithelialization, and alleviated tissue hypoxia. This study presents an energy\u2010responsive gas\u2010releasing eutectic gel platform for coordinating bioelectric, antibacterial, and immunoregulatory cures to accelerate infected wound repair.\n                  <\/jats:p>","DOI":"10.1002\/smll.75178","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:12:36Z","timestamp":1786515156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010Activated Eutectic Gels Producing Centripetal Thermoelectric Currents and CO Release to Modulate Calcium\u2010Associated Repair of Infected Wounds"],"prefix":"10.1002","volume":"22","author":[{"given":"Jiamen","family":"Shen","sequence":"first","affiliation":[{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine Vision, and Brain Health) National Key Laboratory of Macromolecular Drugs and Large\u2010scale Preparation The First Affiliated Hospital of Wenzhou Medical 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