{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:03:35Z","timestamp":1790006615220,"version":"4.0.1"},"reference-count":245,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nanozymes are engineered nanomaterials possessing intrinsic enzyme\u2010mimetic catalytic activities that enable regulation of reactive oxygen species (ROS). Initially developed for superoxide dismutase\u2010, catalase\u2010, and peroxidase\u2010like antioxidant functions, nanozymes are increasingly recognized as modulators of immune responses through redox\u2010dependent mechanisms. Given that ROS participate in immune activation, metabolic regulation, and inflammatory resolution, controlled catalytic modulation offers a strategy for disease\u2010specific immune regulation. This review summarizes recent advances in nanozyme\u2010mediated immunomodulation and discusses how macrophages, neutrophils, dendritic cells, and T lymphocytes respond to redox perturbations. In contrast to prior reviews that classify nanozymes mainly by composition or catalytic type, we propose a redox\u2013immune set\u2010point framework that integrates cell\u2010specific immunometabolism, disease\u2010distorted redox landscapes, and nanozyme design principles. We categorize cerium\u2010, manganese\u2010, iron\u2010based, and metal\u2010free nanozymes according to catalytic properties and therapeutic applications. Across chronic inflammatory disorders, impaired wound healing, tumor microenvironments, and sterile neuroinflammatory or cardiovascular injury, nanozymes demonstrate distinct immune regulatory patterns, including resolution restoration, regenerative coordination, antitumor immune reactivation, and attenuation of inflammasome\u2010associated damage. Finally, we address translational challenges such as spatiotemporal control, cell\u2010specific targeting, biodegradability, and biosafety, emphasizing the importance of precision redox engineering for future clinical development.<\/jats:p>","DOI":"10.1002\/smll.75181","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:34:41Z","timestamp":1786599281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulatory Nanozymes as Programmable Redox\u2013Immune Set\u2010Point Regulators"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0933-3763","authenticated-orcid":false,"given":"Sumi","family":"Choi","sequence":"first","affiliation":[{"name":"School of Integrative Engineering Chung\u2010Ang University  Seoul Republic of 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