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However, the poor immunogenicity of released tumor\u2010associated protein antigens (TAAs) remains a major limitation to their therapeutic efficacy. Herein, we developed mannose\u2010loaded hollow polydopamine nanoparticles (Man@HDA\u2010Pd) and proposed intratumoral\u2010Maillard reaction as a new strategy for the glycation of TAAs. The local administration of as\u2010prepared Man@HDA\u2010Pd could efficiently induce ICD effects, leading to the release of abundant TAAs. Furthermore, leveraging the photothermal effect, catalase\u2010like properties of Man@HDA\u2010Pd, these released TAAs undergo mannose\u2010directed glycation via the Maillard reaction, further generating advanced glycation end products (AGEs)\u2010like antigens (denoted as Man\u2010TAAs), thereby endowing them with dendritic cell (DC)\u2010targeting ability and significantly improving their internalization. Concurrently, this man\u2010mediated glycation process is accompanied by elevated reactive oxygen species (ROS), suppressed cell proliferation, and exhibited characteristics of cellular senescence within tumor cells. Additionally, the delivery of Man@HDA\u2010Pd competitively displaces glycans on the immunosuppressive glycoprotein PD\u2010L1 on tumor cell surfaces via a sugar\u2010replacement effect, which would impair its function and inhibit tumor immune escape. Taken together, this work proposes and validates an in situ Maillard\u2010based glycation strategy for enhanced immunotherapy, providing valuable insights for the design of in situ tumor vaccines.<\/jats:p>","DOI":"10.1002\/smll.75185","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:21:22Z","timestamp":1786378882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mannose Glycation of Tumor\u2010Associated Antigens via Intratumoral Maillard Reaction Mediated by a Photothermal Nano\u2010Catalyst for Enhanced Antigen\u2010Presenting Cell Targeting"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-5370","authenticated-orcid":false,"given":"Jingsong","family":"Lu","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Zhejiang University of Technology  Hangzhou China"},{"name":"Research Center of Magnetic 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