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Herein, we developed a bionic protein bond constraint strategy to construct multifunctional quaternary ammonium hydrogel coatings (BEAC). Inspired by the secondary bonds stabilizing the protein tertiary structure, BEAC was synthesized by integrating acryloyloxyethyl trimethylammonium chloride (DAC) with amide\u2010rich hydrophilic components. This architecture establishes bionic bond constraints via hydrogen bonding, ion\u2012dipole interactions, van der Waals forces, etc. The robust BEAC results in a 280% increase in tensile strength over that of the DAC, a low friction coefficient (0.08), and a tissue\u2010matching surface modulus (198.7\u00a0kPa). Furthermore, BEAC promotes the surface enrichment of quaternary ammonium, ensuring superior antifouling, with an antibacterial rate exceeding 99.6%. Consequently, BEAC\u2010modified nasogastric and urinary catheters significantly mitigate foreign body responses and infection risks through dual\u2010action protection. This work provides a promising strategy for designing multifunctional hydrogel coatings, with potential applications for various invasive devices.<\/jats:p>","DOI":"10.1002\/smll.75191","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:14:19Z","timestamp":1787584459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bionic Protein Bond Constraint\u2010Reinforced and Enriched Multifunctional Hydrogel Coating for Invasive Medical Devices"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3250-2109","authenticated-orcid":false,"given":"Yu","family":"Qiu","sequence":"first","affiliation":[{"name":"Medicine and Engineering Interdisciplinary Research Laboratory of Nursing &amp; Materials West China Hospital\/West China School of Nursing Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-4231","authenticated-orcid":false,"given":"Rui","family":"Hong","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6329-7529","authenticated-orcid":false,"given":"DanMei","family":"Liang","sequence":"additional","affiliation":[{"name":"Medicine and Engineering Interdisciplinary Research Laboratory of Nursing &amp; 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