{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:26:40Z","timestamp":1787394400835,"version":"3.56.0"},"reference-count":86,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/38\/E\/ST5\/00456"],"award-info":[{"award-number":["2020\/38\/E\/ST5\/00456"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The human skin is highly susceptible to bacterial infections and inflammation when its integrity is disrupted. Treatment of infected wounds is a big challenge in modern medicine, and rising antibiotic resistance motivates the development of antibiotic\u2010free therapies. Here, we present a stimuli\u2010responsive wound dressing that integrates carboxylated eggshell membrane (ESM) with electrosprayed tannic acid\/iron (TAFe) particles trapped between electrospun Poly\u2010L\u2010lactide\u2010caprolactone (PLCL) layers and precisely laser\u2010structured to increase porosity and fit the wound size. The TAFe exhibits stable photothermal conversion and antioxidant activity, eradicating more than 99.5% of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ), while maintaining high biocompatibility in vitro. In an infected rat model, the sandwich\u2010like ESMmod\/PLCL\/TAFe dressing accelerated closure and achieved near\u2010complete healing, with residual wound area &lt;1% by day 14. Analysis shows that the material promotes M2\u2010mediated reparative microenvironment, which, in consequence, suppresses TNF\u03b1 and IL\u20106, a pro\u2010inflammatory cytokines, and enhances angiogenesis through increased CD31 and VEGF levels. Moreover, a more organized collagen structure and less scarring were found in the wound bed. Importantly, the material is partially derived from waste, aligning with circular economy principles and reducing resource burden. The versatile composite offers an antibiotic\u2010free strategy that disinfects, modulates inflammation, and promotes regeneration of infected wounds.\n                  <\/jats:p>","DOI":"10.1002\/smll.75193","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:01:22Z","timestamp":1787392882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010Light\u2010Activable Macrophage Polarization Orchestration Using Laser\u2010Structured Janus Nanoplatform Derived from Waste for Infected Wound Healing"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-8810","authenticated-orcid":false,"given":"Daniel","family":"Rybak","sequence":"first","affiliation":[{"name":"Department of Biosystems and Soft Matter Institute of Fundamental Technological Research Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Burn Research Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2607-7271","authenticated-orcid":false,"given":"Alicja","family":"Kosik\u2010Kozio\u0142","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Soft Matter Institute of Fundamental Technological Research Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-5479","authenticated-orcid":false,"given":"Zuzanna J.","family":"Krysiak","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Soft Matter Institute of Fundamental Technological Research Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-701X","authenticated-orcid":false,"given":"Pawe\u0142","family":"Nakielski","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Soft Matter Institute of Fundamental Technological Research Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Bartolewska","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Soft Matter Institute of Fundamental Technological Research Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Zawadzka","sequence":"additional","affiliation":[{"name":"Department of Nanobiotechnology Institute of Biology Warsaw University of Life Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-584X","authenticated-orcid":false,"given":"Micha\u0142","family":"Pruchniewski","sequence":"additional","affiliation":[{"name":"Department of Nanobiotechnology Institute of Biology Warsaw University of Life Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zakrzewska","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Soft Matter Institute of Fundamental Technological Research Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Wierzbicki","sequence":"additional","affiliation":[{"name":"Department of Nanobiotechnology Institute of Biology Warsaw University of Life Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-2813","authenticated-orcid":false,"given":"Massimiliano","family":"Lanzi","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry \u201cToso Montanari\u201d University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-213X","authenticated-orcid":false,"given":"Yunlong","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Burn Research Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-4141","authenticated-orcid":false,"given":"Filippo","family":"Pierini","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Soft Matter Institute of Fundamental Technological Research Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901502","article-title":"Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing","volume":"9","author":"Xu Z.","year":"2020","journal-title":"Advanced Healthcare Materials"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1021\/acsnano.9b09282","article-title":"Well\u2010Defined Gold Nanorod\/Polymer Hybrid Coating with Inherent Antifouling and Photothermal Bactericidal Properties for Treating an Infected Hernia","volume":"14","author":"Zhao Y.\u2010Q.","year":"2020","journal-title":"ACS Nano"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202306602","article-title":"Hyaluronidase\u2010Responsive Bactericidal Cryogel for Promoting Healing of Infected Wounds: Inflammatory Attenuation, ROS Scavenging, and Immune Regulation","volume":"11","author":"Liu M.","year":"2024","journal-title":"Advanced Science"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"18907","DOI":"10.1021\/acsami.9b02915","article-title":"Practical Preparation of Infection\u2010Resistant Biomedical Surfaces from Antimicrobial \u03b2\u2010Peptide Polymers","volume":"11","author":"Qi F.","year":"2019","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s10570-021-04289-5","article-title":"A Facile Strategy to Fabricate Silver\u2010Functionalized Superhydrophobic Cotton Fabrics with Long\u2010Term Antibacterial Properties","volume":"29","author":"Ye Z.","year":"2022","journal-title":"Cellulose"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"15014","DOI":"10.1021\/acsami.8b22136","article-title":"Rapid and Highly Effective Noninvasive Disinfection by Hybrid Ag\/CS@MnO2 Nanosheets Using Near\u2010Infrared Light","volume":"11","author":"Wang X.","year":"2019","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"54328","DOI":"10.1021\/acsami.0c13266","article-title":"Multifunctional Platform Based on Electrospun Nanofibers and Plasmonic Hydrogel: A Smart Nanostructured Pillow for Near\u2010Infrared Light\u2010Driven Biomedical Applications","volume":"12","author":"Nakielski P.","year":"2020","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","DOI":"10.1002\/admt.202400450","article-title":"Solar\u2010to\u2010NIR Light Activable PHBV\/ICG Nanofiber\u2010Based Face Masks With On\u2010Demand Combined Photothermal and Photodynamic Antibacterial Properties","volume":"10","author":"Haghighat Bayan M. A.","year":"2024","journal-title":"Advanced Materials Technologies"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1039\/D3BM01125A","article-title":"Engineering Surgical Face Masks with Photothermal and Photodynamic Plasmonic Nanostructures for Enhancing Filtration and On\u2010Demand Pathogen Eradication","volume":"12","author":"Haghighat Bayan M. A.","year":"2023","journal-title":"Biomaterials Science"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404274","article-title":"NIR\u2010Light Activable 3D Printed Platform Nanoarchitectured with Electrospun Plasmonic Filaments for on Demand Treatment of Infected Wounds","volume":"14","author":"Rybak D.","year":"2025","journal-title":"Advanced Healthcare Materials"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.124888","article-title":"Conductive Adhesive Self\u2010Healing Nanocomposite Hydrogel Wound Dressing for Photothermal Therapy of Infected Full\u2010Thickness Skin Wounds","volume":"394","author":"He J.","year":"2020","journal-title":"Chemical Engineering Journal"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.148938","article-title":"Photothermal Microneedle Patch Loaded with Antimicrobial Peptide\/MnO2 Hybrid Nanoparticles for Chronic Wound Healing","volume":"482","author":"Wang G.","year":"2024","journal-title":"Chemical Engineering Journal"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202414111","article-title":"Elaborated Bio\u2010Heterojunction with Robust Sterilization Effect for Infected Tissue Regeneration via Activating Competent Cell\u2010Like Antibacterial Tactic","volume":"36","author":"Huang Y.","year":"2024","journal-title":"Advanced Materials"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201904402","article-title":"Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing","volume":"29","author":"Yu Y.","year":"2019","journal-title":"Advanced Functional Materials"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1021\/acsnano.8b01456","article-title":"Metal Ion\/Tannic Acid Assembly as a Versatile Photothermal Platform in Engineering Multimodal Nanotheranostics for Advanced Applications","volume":"12","author":"Liu T.","year":"2018","journal-title":"ACS Nano"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143173","article-title":"Immunoregulatory Hydrogel Decorated with Tannic Acid\/Ferric Ion Accelerates Diabetic Wound Healing via Regulating Macrophage Polarization","volume":"466","author":"Xu N.","year":"2023","journal-title":"Chemical Engineering Journal"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1002\/anie.201311136","article-title":"Engineering Multifunctional Capsules through the Assembly of Metal\u2013Phenolic Networks","volume":"53","author":"Guo J.","year":"2014","journal-title":"Angewandte Chemie International Edition"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101808","article-title":"One\u2010Step Synthesis of Multifunctional Chitosan Hydrogel for Full\u2010Thickness Wound Closure and Healing","volume":"11","author":"Guo S.","year":"2022","journal-title":"Advanced Healthcare Materials"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"28511","DOI":"10.1021\/acsami.6b10491","article-title":"Antibacterial and Anti\u2010Inflammatory pH\u2010Responsive Tannic Acid\u2010Carboxylated Agarose Composite Hydrogels for Wound Healing","volume":"8","author":"Ninan N.","year":"2016","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202501242","article-title":"Sprayable Photothermal Fiber\u2010Embedded Hydrogels to Engineer Microenvironment for Infected Wound Healing","volume":"35","author":"Du J.","year":"2025","journal-title":"Advanced Functional Materials"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001122","article-title":"Hydrogen\u2010Bonded Extracellular Matrix\u2010Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH\u2010Responsive Wound Healing Acceleration","volume":"10","author":"Ahmadian Z.","year":"2021","journal-title":"Advanced Healthcare Materials"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119398","article-title":"Novel H2S\u2010Releasing Hydrogel for Wound Repair via In Situ Polarization of M2 Macrophages","volume":"222","author":"Wu J.","year":"2019","journal-title":"Biomaterials"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152131","article-title":"Programming of Macrophage Polarization in Different Stages for Accelerating Wound Healing","volume":"491","author":"Zhu M.","year":"2024","journal-title":"Chemical Engineering Journal"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.133859","article-title":"An M2 Macrophage\u2010Polarized Anti\u2010Inflammatory Hydrogel Combined with Mild Heat Stimulation for Regulating Chronic Inflammation and Impaired Angiogenesis of Diabetic Wounds","volume":"433","author":"Yuan Y.","year":"2022","journal-title":"Chemical Engineering Journal"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20230066","article-title":"Recent Advances in Reactive Oxygen Species Scavenging Nanomaterials for Wound Healing","volume":"4","author":"Joorabloo A.","year":"2024","journal-title":"Exploration (Beijing)"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.110569","article-title":"NIR Stimulated Epigallocatechin Gallate Loaded Polydopamine With Enhanced Antibacterial and ROS Scavenging Abilities for Improved Infectious Wound Healing","volume":"36","author":"Wang J.","year":"2024","journal-title":"Chinese Chemical Letters"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112350","article-title":"Beneficial Effect on Rapid Skin Wound Healing through Carboxylic Acid\u2010treated Chicken Eggshell Membrane","volume":"128","author":"Choi H. J.","year":"2021","journal-title":"Materials Science and Engineering: C"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","article-title":"Transition from Inflammation to Proliferation: a Critical Step during Wound Healing","volume":"73","author":"Land\u00e9n N. X.","year":"2016","journal-title":"Cellular and Molecular Life Sciences"},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.msec.2016.05.005","article-title":"Soluble Eggshell Membrane: a Natural Protein to Improve the Properties of Biomaterials Used for Tissue Engineering Applications","volume":"67","author":"Sah M. K.","year":"2016","journal-title":"Materials Science and Engineering: C"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/j.foodchem.2013.04.115","article-title":"Hydrogen Peroxide Treatment of Eggshell Membrane to Control Porosity","volume":"141","author":"Hsieh S.","year":"2013","journal-title":"Food Chemistry"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1021\/jf4003939","article-title":"Biosorption of Multifold Toxic Heavy Metal Ions from Aqueous Water onto Food Residue Eggshell Membrane Functionalized with Ammonium Thioglycolate","volume":"61","author":"Wang S.","year":"2013","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/term.3178","article-title":"Preparation and Characterization of a Soluble Eggshell Membrane\/Agarose Composite Scaffold with Possible Applications in Cartilage Regeneration","volume":"15","author":"Been S.","year":"2021","journal-title":"Journal of Tissue Engineering and Regenerative Medicine"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2023.1116126","article-title":"Advances in Eggshell Membrane Separation and Solubilization Technologies","volume":"10","author":"Han C.","year":"2023","journal-title":"Frontiers in Veterinary Science"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.msec.2018.10.054","article-title":"Processed Eggshell Membrane Powder: Bioinspiration for an Innovative Wound Healing Product","volume":"95","author":"Ahmed T. A. E.","year":"2019","journal-title":"Materials Science and Engineering: C"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"76019","DOI":"10.1039\/C5RA09959E","article-title":"Egg Shell Membrane \u2013 A Potential Natural Scaffold for human Meniscal Tissue Engineering: An In Vitro Study","volume":"5","author":"Pillai M. M.","year":"2015","journal-title":"RSC Advances"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jbm.a.31606","article-title":"Preparation and Immobilization of Soluble Eggshell Membrane Protein on the Electrospun Nanofibers to Enhance Cell Adhesion and Growth","volume":"86","author":"Jia J.","year":"2008","journal-title":"Journal of Biomedical Materials Research Part A"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.compositesb.2012.09.059","article-title":"Improving Mechanical Properties of Alginate Hydrogel by Reinforcement with Ethanol Treated Polycaprolactone Nanofibers","volume":"45","author":"Jang J.","year":"2013","journal-title":"Composites Part B: Engineering"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202104971","article-title":"Laser\u2010Assisted Fabrication of Injectable Nanofibrous Cell Carriers","volume":"18","author":"Nakielski P.","year":"2022","journal-title":"Small"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1021\/acs.biomac.8b00142","article-title":"Toward Semistructural Cellulose Nanocomposites: the Need for Scalable Processing and Interface Tailoring","volume":"19","author":"Ansari F.","year":"2018","journal-title":"Biomacromolecules"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119978","article-title":"The Effect of a Nanofiber\u2010Hydrogel Composite on Neural Tissue Repair and Regeneration in the Contused Spinal Cord","volume":"245","author":"Li X.","year":"2020","journal-title":"Biomaterials"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1039\/D3TB02693K","article-title":"Injectable and Self\u2010Healable Nano\u2010Architectured Hydrogel for NIR\u2010Light Responsive Chemo\u2010 and Photothermal Bacterial Eradication","volume":"12","author":"Rybak D.","year":"2024","journal-title":"Journal of Materials Chemistry B"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"58103","DOI":"10.1021\/acsami.3c11710","article-title":"Minimally Invasive Intradiscal Delivery of BM\u2010MSCs via Fibrous Microscaffold Carriers","volume":"15","author":"Nakielski P.","year":"2023","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202404963","article-title":"Injectable PLGA Microscaffolds with Laser\u2010Induced Enhanced Microporosity for Nucleus Pulposus Cell Delivery","volume":"21","author":"Nakielski P.","year":"2025","journal-title":"Small"},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1021\/acs.biomac.3c00175","article-title":"Bioinspired PLCL\/Elastin Nanofibrous Vascular Tissue Engineering Scaffold Enhances Endothelial Cells and Inhibits Smooth Muscle Cells","volume":"24","author":"Wang X.","year":"2023","journal-title":"Biomacromolecules"},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1016\/j.actbio.2012.04.023","article-title":"Femtosecond Laser Ablation Enhances Cell Infiltration into Three\u2010Dimensional Electrospun Scaffolds","volume":"8","author":"Lee B. L.\u2010P.","year":"2012","journal-title":"Acta Biomaterialia"},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s41598-017-00594-x","article-title":"Nano\u2010Silver\u2010Decorated Microfibrous Eggshell Membrane: Processing, Cytotoxicity Assessment and Optimization, Antibacterial Activity and Wound Healing","volume":"7","author":"Liu M.","year":"2017","journal-title":"Scientific Reports"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1021\/acsami.1c24576","article-title":"Tannic Acid\u2013Iron Complex\u2010Based Nanoparticles as a Novel Tool against Oxidative Stress","volume":"14","author":"Pucci C.","year":"2022","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","first-page":"27937","DOI":"10.1021\/acsomega.2c01679","article-title":"Analysis of Iron Complexes of Tannic Acid and Other Related Polyphenols as Revealed by Spectroscopic Techniques: Implications in the Identification and Characterization of Iron Gall Inks in Historical Manuscripts","volume":"7","author":"Espina A.","year":"2022","journal-title":"ACS Omega"},{"key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1039\/c3tb20241k","article-title":"Trans\u2010differentiation of Human Mesenchymal Stem Cells Generates Functional Hepatospheres on Poly(l\u2010lactic acid)\u2010co\u2010poly(\u03b5\u2010caprolactone)\/Collagen Nanofibrous Scaffolds","volume":"1","author":"Bishi D. K.","year":"2013","journal-title":"Journal of Materials Chemistry B"},{"key":"e_1_2_9_51_1","first-page":"4709","article-title":"Biocomposite Nanofibrous Strategies for the Controlled Release of Biomolecules for Skin Tissue Regeneration","volume":"9","author":"Gandhimathi C.","year":"2014","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_9_52_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.colsurfa.2015.07.061","article-title":"Coating Process and Stability of Metal\u2010polyphenol Film","volume":"484","author":"Yang L.","year":"2015","journal-title":"Colloids and Surfaces A: Physicochemical and Engineering Aspects"},{"key":"e_1_2_9_53_1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.ijbiomac.2017.11.035","article-title":"Nanochitosan Enriched Poly \u03b5\u2010caprolactone Electrospun Wound Dressing Membranes: A Fine Tuning of Physicochemical Properties, Hemocompatibility and Curcumin Release Profile","volume":"108","author":"Cr R.","year":"2018","journal-title":"International Journal of Biological Macromolecules"},{"key":"e_1_2_9_54_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2022.108563","article-title":"Electrospun Poly (\u0190\u2010caprolactone)\u2010Eggshell Membrane Nanofibrous Mat as a Potential Wound Dressing Material","volume":"187","author":"Bello M.","year":"2022","journal-title":"Biochemical Engineering Journal"},{"key":"e_1_2_9_55_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/pat.5528","article-title":"Biodegradable Highly Porous Interconnected Poly(\u03b5\u2010caprolactone)\/Poly(L\u2010lactide\u2010co\u2010\u03b5\u2010caprolactone) Scaffolds by Supercritical Foaming for Small\u2010Diameter Vascular Tissue Engineering","volume":"33","author":"Cao Y.","year":"2022","journal-title":"Polymers for Advanced Technologies"},{"key":"e_1_2_9_56_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.addma.2023.103936","article-title":"Improved Interlayer Performance of Short Carbon Fiber Reinforced Composites with Bio\u2010Inspired Structured Interfaces","volume":"79","author":"Zhang M.","year":"2024","journal-title":"Additive Manufacturing"},{"key":"e_1_2_9_57_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.actamat.2020.116546","article-title":"Micromechanical Behavior of Multilayered Ti\/Nb Composites Processed by Accumulative Roll Bonding: an in\u2010situ Synchrotron X\u2010Ray Diffraction Investigation","volume":"205","author":"Jiang S.","year":"2021","journal-title":"Acta Materialia"},{"key":"e_1_2_9_58_1","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.1039\/D3NR00807J","article-title":"Evolution of Nanostructured Skin Patches towards Multifunctional Wearable Platforms for Biomedical Applications","volume":"15","author":"Rybak D.","year":"2023","journal-title":"Nanoscale"},{"key":"e_1_2_9_59_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep24596","article-title":"Controlled Water Vapor Transmission Rate Promotes Wound\u2010Healing via Wound Re\u2010Epithelialization and Contraction Enhancement","volume":"6","author":"Xu R.","year":"2016","journal-title":"Scientific Reports"},{"key":"e_1_2_9_60_1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1021\/acsabm.8b00169","article-title":"Surface Modification of Eggshell Membrane with Electrospun Chitosan\/Polycaprolactone Nanofibers for Enhanced Dermal Wound Healing","volume":"1","author":"Guha Ray P.","year":"2018","journal-title":"ACS Applied Bio Materials"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1039\/C5TB00226E","article-title":"Fabrication of a Novel Blended Membrane with Chitosan and Silk Microfibers for Wound Healing: Characterization, In Vitro and In Vivo Studies","volume":"3","author":"Xu Z.","year":"2015","journal-title":"Journal of Materials Chemistry B"},{"key":"e_1_2_9_62_1","first-page":"0591","article-title":"Recent Advances in Asymmetric Wettability Dressings for Wound Exudate Management","volume":"8","author":"Wang F.","year":"2025","journal-title":"Research (Wash D C)"},{"key":"e_1_2_9_63_1","doi-asserted-by":"crossref","first-page":"25275","DOI":"10.1021\/acs.langmuir.4c03631","article-title":"Complementary Superwetting Structures Treated by a Femtosecond Laser for Simultaneous Spontaneous Directional Transport of Water Droplets and Underwater Bubbles","volume":"40","author":"Yang S.","year":"2024","journal-title":"Langmuir"},{"key":"e_1_2_9_64_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s40820-022-00840-6","article-title":"Femtosecond Laser Thermal Accumulation\u2010Triggered Micro\u2010\/Nanostructures with Patternable and Controllable Wettability towards Liquid Manipulating","volume":"14","author":"Yin K.","year":"2022","journal-title":"Nano\u2010Micro Letters"},{"key":"e_1_2_9_65_1","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s42003-024-07219-w","article-title":"Cellular and Molecular Roles of Reactive Oxygen Species in Wound Healing","volume":"7","author":"Hunt M.","year":"2024","journal-title":"Communications Biology"},{"key":"e_1_2_9_66_1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3390\/antiox12040787","article-title":"Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review","volume":"12","author":"Fadilah N. I. M.","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"e_1_2_9_67_1","doi-asserted-by":"crossref","DOI":"10.1002\/biot.70117","article-title":"Exploring the Activities of Alginate\u2010Carrageenan@AgNPs Hydrogels Supported by Molecular Docking Studies for Potential Antimicrobial and Antioxidant Agents","volume":"20","author":"Dawwam G. E.","year":"2025","journal-title":"Biotechnology Journal"},{"key":"e_1_2_9_68_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3390\/ph17050575","article-title":"Characterization, Biocompatibility and Antioxidant Activity of Hydrogels Containing Propolis Extract as an Alternative Treatment in Wound Healing","volume":"17","author":"Meneses Costa Ferreira L. M.","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"e_1_2_9_69_1","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1007\/s12274-022-4555-4","article-title":"Novel Gold Nanoparticles Targeting Somatostatin Receptor Subtype Two with Near\u2010Infrared Light for Neuroendocrine Tumour Therapy","volume":"15","author":"Chen Q.","year":"2022","journal-title":"Nano Research"},{"key":"e_1_2_9_70_1","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad076","article-title":"NIR\u2010responsive Carrier\u2010free Nanoparticles Based on Berberine Hydrochloride and Indocyanine Green for Synergistic Antibacterial Therapy and Promoting Infected Wound Healing","volume":"10","author":"Duan Y.","year":"2023","journal-title":"Regenerative Biomaterials"},{"key":"e_1_2_9_71_1","doi-asserted-by":"crossref","first-page":"46079","DOI":"10.1021\/acsami.4c09215","article-title":"NIR\u2010II Responsive Fe\u2010Doped Carbon Nanoparticles for Photothermal\u2010Enhanced Chemodynamic Synergistic Oncotherapy","volume":"16","author":"Wang X.","year":"2024","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_9_72_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.colsurfb.2018.03.030","article-title":"Biocompatible Fe3+\u2013TA Coordination Complex with High Photothermal Conversion Efficiency for Ablation of Cancer Cells","volume":"167","author":"Liu P.\u2010Y.","year":"2018","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"key":"e_1_2_9_73_1","doi-asserted-by":"crossref","first-page":"65756","DOI":"10.1039\/C6RA07681E","article-title":"POSS\u2013PU Electrospinning Nanofibers Membrane with Enhanced Blood Compatibility","volume":"6","author":"Song X.","year":"2016","journal-title":"RSC Advances"},{"key":"e_1_2_9_74_1","doi-asserted-by":"crossref","first-page":"11686","DOI":"10.1021\/acsnano.9b05608","article-title":"pH\u2010Switchable Antimicrobial Nanofiber Networks of Hydrogel Eradicate Biofilm and Rescue Stalled Healing in Chronic Wounds","volume":"13","author":"Wang J.","year":"2019","journal-title":"ACS Nano"},{"key":"e_1_2_9_75_1","doi-asserted-by":"crossref","first-page":"11883","DOI":"10.2147\/IJN.S484473","article-title":"How Nanoparticles Help in Combating Chronic Wound Biofilms Infection?","volume":"19","author":"Jing G.","year":"2024","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_9_76_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202506791","article-title":"Emerging Smart Biomaterials\/Devices to Accelerate Chronic Wound Healing by Modulating Wound Microenvironments","volume":"21","author":"Barik S.","year":"2025","journal-title":"Small"},{"key":"e_1_2_9_77_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128027","article-title":"Mild Hyperthermia\u2010assisted Chitosan Hydrogel with Photothermal Antibacterial Property and CAT\u2010Like Activity for Infected Wound Healing","volume":"254","author":"Liu K.","year":"2024","journal-title":"International Journal of Biological Macromolecules"},{"key":"e_1_2_9_78_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1158007","article-title":"Mild\u2010Temperature Photothermal Assisted CuSi Nanowires for Promoting Infected Wound Healing","volume":"11","author":"Feng Y.","year":"2023","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"e_1_2_9_79_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202309624","article-title":"Treatment of Acute Wound Infections by Degradable Polymer Nanoparticle with a Synergistic Photothermal and Chemodynamic Strategy","volume":"11","author":"Chen F.","year":"2024","journal-title":"Advanced Science"},{"key":"e_1_2_9_80_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1089\/jmf.2011.0197","article-title":"Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor\u2010 \u03b1 Levels after In Vitro Digestion","volume":"15","author":"Benson K. F.","year":"2012","journal-title":"Journal of Medicinal Food"},{"key":"e_1_2_9_81_1","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1039\/D0BM01110J","article-title":"A Novel Eco\u2010friendly Green Approach to Produce Particalized Eggshell Membrane (PEM) for Skin Health Applications","volume":"8","author":"Kulshreshtha G.","year":"2020","journal-title":"Biomaterials Science"},{"key":"e_1_2_9_82_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41419-020-02737-x","article-title":"Targeted Inhibition of Endothelial Calpain Delays Wound Healing by Reducing Inflammation and Angiogenesis","volume":"11","author":"Yi C.","year":"2020","journal-title":"Cell Death & Disease"},{"key":"e_1_2_9_83_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-23304-8","article-title":"Overexpression of VEGF in Dermal Fibroblast Cells Accelerates the Angiogenesis and Wound Healing Function: in Vitro and in Vivo Studies","volume":"12","author":"Shams F.","year":"2022","journal-title":"Scientific Reports"},{"key":"e_1_2_9_84_1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3390\/biomedicines11041089","article-title":"Correlation between Collagen Type I\/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast\u2010Conserving Surgery","volume":"11","author":"Kim H.\u2010Y.","year":"2023","journal-title":"Biomedicines"},{"key":"e_1_2_9_85_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.35335\/jmn.v6i2.5034","article-title":"The Effectiveness of Hydrocolloid Dressing in Post\u2010operative Wound Healing: A Narrative Review","volume":"6","author":"Hastuti H.","year":"2024","journal-title":"Journal of Midwifery Nursing"},{"key":"e_1_2_9_86_1","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1002\/nop2.1867","article-title":"Efficacy of Different Types of Dressings on Pressure Injuries: Systematic Review and Network Meta\u2010Analysis","volume":"10","author":"Zhang C.","year":"2023","journal-title":"Nursing Open"},{"key":"e_1_2_9_87_1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.apjtb.2015.06.003","article-title":"Efficient Solvent Extraction of Antioxidant\u2010rich Extract from a Tropical Diatom, Chaetoceros Calcitrans (Paulsen) Takano 1968","volume":"5","author":"Foo S. C.","year":"2015","journal-title":"Asian Pacific Journal of Tropical Biomedicine"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:01:32Z","timestamp":1787392892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":86,"alternative-id":["10.1002\/smll.75193"],"URL":"https:\/\/doi.org\/10.1002\/smll.75193","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75193"}}