{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:30:32Z","timestamp":1786703432041,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177009"],"award-info":[{"award-number":["22177009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7262226"],"award-info":[{"award-number":["7262226"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Renal ischemia\u2010reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), yet early diagnosis remains challenging owing to the lack of sensitive and specific approaches for in vivo inflammation visualization, which severely limits accurate diagnosis and effective intervention. To address this limitation, this work reports an inflammation\u2010targeting multiparametric MRI strategy based on a nanoprobe (NPs@PEG\u2010PEP) for real\u2010time visualization of AKI\u2010associated inflammatory responses. NPs@PEG\u2010PEP was modified with functional peptides targeting CD137, which is an activation\u2010induced immune receptor serving as an upstream mediator of inflammatory cascades. This approach enables nanoprobes to selectively target and accumulate surrounding inflammatory cells in AKI\u2010affected kidneys. In addition, constructed from NaGdF\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles, the nanoprobe simultaneously enhances dynamic contrast\u2010enhanced MRI (DCE\u2010MRI) and susceptibility\u2010weighted imaging (SWI) to capture distinct vascular perfusion differences and inflammatory cell infiltration between injured and contralateral kidneys. The inflammatory imaging signal persists for up to 18\u00a0h and correlates well with histopathological findings, including H&amp;E staining and CD11b immunofluorescence. Moreover, the biological safety of the nanoprobe is confirmed via cytotoxicity assays, hemolysis tests, and histopathological evaluations. Overall, this work establishes an inflammation\u2010targeting multiparametric MRI platform that enables spatiotemporal mapping of IRI\u2010induced AKI progression, offering a promising strategy for early diagnosis and therapeutic monitoring.\n                  <\/jats:p>","DOI":"10.1002\/smll.75221","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:44:32Z","timestamp":1786700672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiparametric MRI for In Vivo Visualization of Renal Inflammation in Acute Kidney Injury"],"prefix":"10.1002","author":[{"given":"Chuang","family":"Liu","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering, and College of Life Science and Technology Beijing University of Chemical Technology  Beijing People's Republic of China"},{"name":"CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5146-8389","authenticated-orcid":false,"given":"Shuai","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, and College of Life Science and Technology Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, and College of Life Science and Technology Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, and College of Life Science and Technology Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, and College of Life Science and Technology Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Ao","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"Li","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, and College of Life Science and Technology Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-6929","authenticated-orcid":false,"given":"Yi","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, and College of Life Science and Technology Beijing University of Chemical Technology  Beijing People's Republic of 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